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High-resolution dynamic mapping of histone-DNA interactions in a nucleosome
Open accessAbstract
The nature of the nucleosomal barrier that regulates access to the underlying DNA during many cellular processes is not fully understood. Here we present a detailed map of histone-DNA interactions along the DNA sequence to near base pair accuracy by mechanically unzipping single molecules of DNA, each containing a single nucleosome. This interaction map revealed a distinct ∼5-bp periodicity that was enveloped by three broad regions of strong interactions, with the strongest occurring at the dyad and the other two about ±40-bp from the dyad. Unzipping up to the dyad allowed recovery of a canonical nucleosome upon relaxation of the DNA, but unzipping beyond the dyad resulted in removal of the histone octamer from its initial DNA sequence. These findings have important implications for how RNA polymerase and other DNA-based enzymes may gain access to DNA associated with a nucleosome.
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Cites
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883
Brower-Toland, B., Wacker, D. A., Fulbright, R. M., Lis, J. T., Kraus, W. L., & Wang, M. D. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.11.056 · Cited by 198
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Cited by
Histone core modifications regulating nucleosome structure and dynamics
Tessarz, P., & Kouzarides, T. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3890 · Cited by 1,018
Lateral Thinking: How Histone Modifications Regulate Gene Expression
Lawrence, M., Daujat, S., & Schneider, R. (2016) · Trends in Genetics · doi:10.1016/j.tig.2015.10.007 · Cited by 908
Precise Maps of RNA Polymerase Reveal How Promoters Direct Initiation and Pausing
Kwak, H., Fuda, N. J., Core, L. J., & Lis, J. T. (2013) · Science · doi:10.1126/science.1229386 · Cited by 849
Self-citationNascent transcript sequencing visualizes transcription at nucleotide resolution
Churchman, L. S., & Weissman, J. S. (2011) · Nature · doi:10.1038/nature09652 · Cited by 823
Optical tweezers in single-molecule biophysics
Bustamante, C. J., Chemla, Y. R., Liu, S., & Wang, M. D. (2021) · Nature Reviews Methods Primers · doi:10.1038/s43586-021-00021-6 · Cited by 615
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Metadata
- Authors
- Hall, M. A., Shundrovsky, A., Bai, L., Fulbright, R. M., Lis, J. T., & Wang, M. D.
- Venue
- Nature Structural & Molecular Biology
- Published
- 2009-01-11
- Volume
- 16
- Issue
- 2
- Pages
- 124-129
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W2077547710
- Cited by
- 385
- References
- 2
- FWCI
- 8.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Hall, M. A., Shundrovsky, A., Bai, L., Fulbright, R. M., Lis, J. T., & Wang, M. D. (2009). High-resolution dynamic mapping of histone-DNA interactions in a nucleosome. Nature Structural & Molecular Biology. https://doi.org/10.1038/nsmb.1526
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