The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping
Open accessAbstract
The tumor suppressor protein BRCA2 is a key component of the homologous recombination pathway of DNA repair, acting as the loader of RAD51 recombinase at sites of double-strand breaks. Here we show that BRCA2 associates with telomeres during the S and G2 phases of the cell cycle and facilitates the loading of RAD51 onto telomeres. Conditional deletion of Brca2 and inhibition of Rad51 in mouse embryonic fibroblasts (MEFs), but not inactivation of Brca1, led to shortening of telomeres and accumulation of fragmented telomeric signals—a hallmark of telomere fragility that is associated with replication defects. These findings suggest that BRCA2-mediated homologous recombination reactions contribute to the maintenance of telomere length by facilitating telomere replication and imply that BRCA2 has an essential role in maintaining telomere integrity during unchallenged cell proliferation. Mouse mammary tumors that lacked Brca2 accumulated telomere dysfunction–induced foci. Human breast tumors in which BRCA2 was mutated had shorter telomeres than those in which BRCA1 was mutated, suggesting that the genomic instability in BRCA2-deficient tumors was due in part to telomere dysfunction.
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A DNA damage checkpoint response in telomere-initiated senescence
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Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
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Self-citationMammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication
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BRCA1 and BRCA2: 1994 and beyond
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Connecting Chromosomes, Crisis, and Cancer
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Disease states associated with telomerase deficiency appear earlier in mice with short telomeres
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Self-citationJacobs, J. J. L., Keblusek, P., Robanus-Maandag, E., Kristel, P., Lingbeek, M., Nederlof, P. M., van Welsem, T., van de Vijver, M. J., Koh, E. Y., Daley, G. Q., et al. (2000) · Nature Genetics · doi:10.1038/81583 · Cited by 368
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RAD51 paralogs: Roles in DNA damage signalling, recombinational repair and tumorigenesis
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Self-citationTargeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds
Zimmer, J., Tacconi, E. M. C., Folio, C., Badie, S., Porru, M., Klare, K., Tumiati, M., Markkanen, E., Halder, S., Ryan, A., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2015.12.004 · Cited by 261
“HR factors, including BRCA2 and RAD51, are required to facilitate telomere replication and to prevent telomere shortening (Badie et al., 2010).”
BackgroundInfluentialSelf-citationComplex interactions between the DNA-damage response and mammalian telomeres
Arnoult, N., & Karlseder, J. (2015) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3092 · Cited by 195
Biomarkers to identify and isolate senescent cells
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Metadata
- Authors
- Badie, S., Escandell, J. M., Bouwman, P., Carlos, A. R., Thanasoula, M., Gallardo, M. M., Suram, A., Jaco, I., Benitez, J., Herbig, U., Blasco, M. A., Jonkers, J., & Tarsounas, M.
- Venue
- Nature Structural & Molecular Biology
- Published
- 2010-11-14
- Volume
- 17
- Issue
- 12
- Pages
- 1461-1469
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W2059956126
- Cited by
- 162
- References
- 9
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Open access
- green
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- Badie, S., Escandell, J. M., Bouwman, P., Carlos, A. R., Thanasoula, M., Gallardo, M. M., Suram, A., Jaco, I., Benitez, J., Herbig, U., Blasco, M. A., Jonkers, J., & Tarsounas, M. (2010). BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping. Nature Structural & Molecular Biology. https://doi.org/10.1038/nsmb.1943
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