A conserved Mediator–CDK8 kinase module association regulates Mediator–RNA polymerase II interaction

Tsai, Kuang-Lei; Sato, Shigeo; Tomomori-Sato, Chieri; Conaway, Ronald C; Conaway, Joan W; Asturias, Francisco J

doi:10.1038/nsmb.2549

A conserved Mediator–CDK8 kinase module association regulates Mediator–RNA polymerase II interaction

The CDK8 kinase module (CKM) is a conserved, dissociable Mediator subcomplex whose component subunits were genetically linked to the RNA polymerase II (RNAPII) C-terminal domain (CTD) and individually recognized as transcriptional repressors before Mediator was identified as a pre-eminent complex…