From guide to target: molecular insights into eukaryotic RNA-interference machinery
Open accessAbstract
Since its relatively recent discovery, RNA interference (RNAi) has emerged as a potent, specific and ubiquitous means of gene regulation. Through a number of pathways that are conserved in eukaryotes from yeast to humans, small noncoding RNAs direct molecular machinery to silence gene expression. In this Review, we focus on mechanisms and structures that govern RNA silencing in higher organisms. In addition to highlighting recent advances, we discuss parallels and differences among RNAi pathways. Together, the studies reviewed herein reveal the versatility and programmability of RNA-induced silencing complexes and emphasize the importance of both upstream biogenesis and downstream silencing factors.
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Most studies show that miRNAs bind to a specific sequence at the 3' UTR of their target mRNAs to induce translational repression and mRNA deadenylation and decapping.
“Most studies to date have shown that miRNAs bind to a specific sequence at the 3′ UTR of their target mRNAs to induce translational repression and mRNA deadenylation and decapping (40, 41).”
From Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018) · cites this paper as [41]
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References 134 · Cited by 281
- Authors
- Ipsaro, J. J., & Joshua-Tor, L.
- Affiliations
- Howard Hughes Medical Institute (US)
- ORCID
- Ipsaro, Jonathan J
- Venue
- Nature Structural & Molecular Biology
- Published
- 2015-01
- Volume
- 22
- Issue
- 1
- Pages
- 20-28
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- PMC
- PMC4450863
- OpenAlex
- W1993324235
- Cited by
- 281
- References
- 134
- Citations by year
- 2026: 18 · 2025: 28 · 2024: 21 · 2023: 26 · 2022: 29 · 2021: 25 · 2020: 38 · 2019: 16 · 2018: 20 · 2017: 19 · 2016: 21 · 2015: 20
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Structural & Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- RNA interference, RNA-induced silencing complex, gene silencing, small RNA, RNAi pathway, RNAi machinery, gene expression regulation
- MeSH terms
- RNA, Untranslated, RNA Interference, Eukaryota
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