A minimal domain responsible for Munc13 activity
Abstract
Munc13 proteins are essential in neurotransmitter release, controlling the priming of synaptic vesicles to a release-ready state. The sequences responsible for this priming activity are unknown. Here we identify a large alpha-helical domain of mammalian Munc13-1 that is autonomously folded and is sufficient to rescue the total arrest in neurotransmitter release observed in hippocampal neurons lacking Munc13s.
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Munc13s execute their priming function via the MUN domain.
“Munc13s execute their priming function via the MUN domain (Basu et al., 2005; Stevens et al., 2005).”
From The Presynaptic Active Zone (2012) · cites this paper as Basu et al., 2005
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References 13 · Cited by 213
- Authors
- Basu, J., Shen, N., Dulubova, I., Lu, J., Guan, R., Guryev, O., Grishin, N. V., Rosenmund, C., & Rizo, J.
- Affiliations
- Baylor College of Medicine (US)
- The University of Texas Southwestern Medical Center (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Rizo, Josep
- Venue
- Nature Structural & Molecular Biology
- Published
- 2005-10-09
- Volume
- 12
- Issue
- 11
- Pages
- 1017-1018
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W2006528183
- Cited by
- 213
- References
- 13
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 4 · 2023: 9 · 2022: 16 · 2021: 8 · 2020: 3 · 2019: 8 · 2018: 10 · 2017: 22 · 2016: 10 · 2015: 7 · 2014: 9 · 2013: 9 · 2012: 9
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Structural & Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Muscular Dystrophy Association
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (NS51262, NS 37200, R01NS037200, R01NS051262)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- Munc13-1, Munc13, neurotransmitter release, synaptic vesicle priming, alpha-helical domain, protein domains, hippocampal neurons, synaptic vesicle exocytosis
- MeSH terms
- Animals, Chromatography, Gel, Exocytosis, Hippocampus, Nerve Tissue Proteins, Neurons, Structure-Activity Relationship, Sucrose, Gene Expression, Protein Structure, Secondary, Protein Structure, Tertiary, Protein Folding, Mice, Knockout, Neurotransmitter Agents, Computational Biology, Excitatory Postsynaptic Potentials, Nuclear Magnetic Resonance, Biomolecular, Mice, Rats
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