Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2
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The X-ray structure at 2.0-A resolution of the p90 ribosomal S6 kinase 2 C-terminal kinase domain revealed a C-terminal autoinhibitory alphaL-helix that was embedded in the kinase scaffold and determines the inactive kinase conformation. We suggest a mechanism of activation through displacement of the alphaL-helix and rearrangement of the conserved residue Glu500, as well as the reorganization of the T-loop into the active conformation.
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The C-terminus of MAPKAPKs is unstructured in all of their protein crystal structures.
“the C-terminus of MAPKAPKs is unstructured in all of their protein crystal structures (32-33).”
From Specificity of Linear Motifs That Bind to a Common Mitogen-Activated Protein Kinase Docking Groove (2012) · cites this paper as [33]
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References 14 · Cited by 48
- Authors
- Malakhova, M., Tereshko, V., Lee, S.-Y., Yao, K., Cho, Y.-Y., Bode, A., & Dong, Z.
- Affiliations
- University of Minnesota (US)
- University of Chicago (US)
- Corresponding author
- Dong, Zigang
- Venue
- Nature Structural & Molecular Biology
- Published
- 2007-12-16
- Volume
- 15
- Issue
- 1
- Pages
- 112-113
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- PMC
- PMC2864125
- OpenAlex
- W1967848166
- Cited by
- 48
- References
- 14
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 5 · 2014: 2 · 2013: 5 · 2012: 7
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Structural & Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (CA 120388, Y1-CO-1020, R01CA111536, CA 077646, R01CA120388, R01CA077646, R01CA081064, R37CA081064, CA111536, R01CA111356, Y01 CO001020, CA081064, CA111356)
- National Institute of General Medical Sciences (Y1-GM-1104, Y01 GM001104)
- National Center for Research Resources (RR 15301, P41RR015301)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Physical Sciences › Materials Science › Materials Chemistry › Enzyme Structure and Function
- Keywords
- RSK, autoinhibition, kinase activation mechanism, inactive kinase conformation, T-loop, protein kinase structure
- MeSH terms
- Enzyme Activation, Models, Molecular, Protein Conformation, Crystallography, X-Ray, Ribosomal Protein S6 Kinases, 90-kDa
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