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Evaluation of serum zonulin for use as an early predictor for gestational diabetes
Open accessAbstract
Diet has an important role in regulating intestinal permeability and subsequently the risk for metabolic disorders. In this observational study, we examined whether serum intestinal permeability marker zonulin, could be used as a predictor for gestational diabetes mellitus (GDM). Serum zonulin concentration was measured in early pregnancy in overweight or obese pregnant women (n=88) at risk for developing GDM. Serum zonulin was associated with higher odds of GDM (adjusted OR for 1 ng ml−1 increase in zonulin: 1.08, 95% CI: 1.02–1.15; P=0.009), diagnosed by a 2-h 75-g oral glucose tolerance test at late pregnancy. The optimal cutoff value was 43.3 ng ml−1, with sensitivity of 88% (95% CI: 71–100%) and specificity of 47% (95% CI: 33–58%). The area under the ROC-curve was 0.67 (95% CI: 0.54–0.81). Our results show an association between increased early-pregnancy serum zonulin concentration and GDM, suggesting zonulin as a possible predictor for GDM.
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Increased "free" plasma/serum ZO-1 is associated with type 1 diabetes (T1DM), T2DM, and GDM.
“Increased “free” plasma/serum ZO-1 is associated with type 1 diabetes (T1DM), T2DM [134], and GDM [135].”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [135]
The Results (page not available) associate higher early-pregnancy serum zonulin with GDM in overweight or obese pregnant women. Citation [135] is attached to GDM, not the T1DM or T2DM portions of the sentence. The paper measures zonulin, however, and does not identify it as “free” ZO-1, so it does not support that specific biomarker claim. (LLM, conf=0.88)
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- Mokkala K, Röytiö H, Munukka E, Pietilä S, Ekblad U, Rönnemaa T et al. Gut microbiota richness and composition and dietary intake of overweight pregnant women are related to serum zonulin concentration, a marker for intestinal permeability. J Nutr 2016; 146: 1694–1700. · DOI
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- Yeral MI, Ozgu-Erdinc AS, Uygur D, Seckin KD, Karsli MF, Danisman AN . Prediction of gestational diabetes mellitus in the first trimester, comparison of fasting plasma glucose, two-step and one-step methods: a prospective randomized controlled trial. Endocrine 2014; 46: 512–518. · DOI
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Cited by
Sorted by citations
The Pathophysiology of Gestational Diabetes Mellitus
Plows, J. F., Stanley, J. L., Baker, P. N., Reynolds, C. M., & Vickers, M. H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113342 · Cited by 1,874
“Increased “free” plasma/serum ZO-1 is associated with type 1 diabetes (T1DM), T2DM [134], and GDM [135].”
Background
Metadata
- Authors
- Mokkala, K., Tertti, K., Rönnemaa, T., Vahlberg, T., & Laitinen, K.
- Affiliations
- University of Turku (FI)
- Corresponding author
- Laitinen, K
- Venue
- Nutrition & Diabetes
- Published
- 2017-03-20
- Volume
- 7
- Issue
- 3
- Pages
- e253-e253
- ISSN
- 2044-4052 (ISSN-L)
- PMC
- PMC5380900
- OpenAlex
- W2601172352
- Cited by
- 41
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 9 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 8 · 2019: 6 · 2018: 3
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nutrition and Diabetes (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UTUPub (University of Turku) (submittedVersion, cc-by)
- Funders
- Academy of Finland (#258606)
- Päivikki ja Sakari Sohlbergin Säätiö
- Turun Yliopistollinen Keskussairaala
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- zonulin, gestational diabetes mellitus, intestinal permeability, early pregnancy, biomarkers, prediction of gestational diabetes, overweight and obesity in pregnancy, cut-off values, sensitivity and specificity
- MeSH terms
- Adult, Blood Glucose, Cholera Toxin, Female, Glucose Tolerance Test, Haptoglobins, Humans, Obesity, Pregnancy, Protein Precursors, Sensitivity and Specificity, Diabetes, Gestational, Overweight
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