(-)-Epigallocatechin-3-gallate inhibits pancreatic lipase and reduces body weight gain in high fat-fed obese mice
Open accessAbstract
Tea (Camellia sinensis, Theaceae) has been shown to have obesity preventive effects in laboratory studies. We hypothesized that dietary epigallocatechin-3-gallate (EGCG) could reverse metabolic syndrome in high fat-fed obese C57bl/6J mice, and that these effects were related to inhibition of pancreatic lipase (PL). Following treatment with 0.32% EGCG for 6 weeks, a 44% decrease in body weight (BW) gain in high fat-fed, obese mice (P < 0.01) was observed compared to controls. EGCG treatment increased fecal lipid content by 29.4% (P < 0.05) compared to high fat-fed control, whereas in vitro, EGCG dose-dependently inhibited PL (IC(50) = 7.5 µmol/l) in a noncompetitive manner with respect to substrate concentration. (-)-Epicatechin-3-gallate exhibited similar inhibitory activity, whereas the nonester-containing (-)-epigallocatechin did not. In conclusion, EGCG supplementation reduced final BW and BW gain in obese mice, and some of these effects may be due to inhibition of PL by EGCG.
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Inhibition of pancreatic lipase decreases the absorption of lipids, which can reduce obesity.
“Therefore, inhibition of pancreatic lipase decreases the absorption of lipids, which can reduce obesity [11,12,13].”
From Separation and Lipid Inhibition Effects of a Novel Decapeptide from Chlorella pyenoidose (2019) · cites this paper as [12]
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References 14 · Cited by 139
- Authors
- Grove, K. A., Sae‐Tan, S., Kennett, M. J., & Lambert, J. D.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Lambert, Joshua D.
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2012-11
- Volume
- 20
- Issue
- 11
- Pages
- 2311-2313
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W2075585729
- Cited by
- 139
- References
- 14
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 6 · 2023: 4 · 2022: 8 · 2021: 12 · 2020: 3 · 2019: 10 · 2018: 12 · 2017: 7 · 2016: 16 · 2015: 11 · 2014: 13 · 2013: 8 · 2012: 5
- FWCI
- 5.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion)
- Funders
- National Center for Complementary and Integrative Health (R01AT004678, AT004678)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- epigallocatechin gallate, pancreatic lipase inhibition, high-fat diet, weight gain, fecal fat excretion, tea polyphenols, Camellia sinensis, metabolic syndrome, non-competitive inhibition, epicatechin-3-gallate, epigallocatechin
- MeSH terms
- Animals, Antioxidants, Body Weight, Catechin, Feces, Lipase, Lipids, Male, Mice, Inbred C57BL, Mice, Obese, Obesity, Metabolic Syndrome, Mice, Diet, High-Fat
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