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Obesity Paradox in Amputation Risk Among Nonelderly Diabetic Men
Open accessAbstract
The association between BMI and amputation risk is not currently well known. We used data for a cohort of diabetic patients treated in the US Department of Veterans Affairs Healthcare System in 2003. Men aged <65 years at the end of follow‐up were examined for their amputation risk and amputation‐free survival during the next 5 years (2004–2008). Compared to overweight individuals (BMI 25–29.9 kg/m 2), the risks of amputation and treatment failure (amputation or death) were higher for patients with BMI <25 kg/m 2 and were lower for those with BMI ≥30 kg/m 2. Individuals with BMI ≥40 kg/m 2 were only half as likely to experience any (hazard ratios (HR) = 0.49; 95% confidence interval (CI), 0.30–0.80) and major amputations (HR = 0.53; 95% CI, 0.39–0.73) during follow‐up as overweight individuals. While the amputation risk continued to decrease for higher BMI, amputation‐free survival showed a slight upturn at BMI >40 kg/m 2. The association between obesity and amputation risk in our data shows a pattern consistent with “obesity paradox” observed in many health conditions. More research is needed to better understand pathophysiological mechanisms that may explain the paradoxical association between obesity and lower‐extremity amputation (LEA) risk.
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The risk of amputation in non-elderly diabetic men decreases with increasing body weight.
“Additionally, a study found that the risk of amputation in non-elderly diabetic men decreased with increasing body weight.137”
From A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives (2021) · cites this paper as [137]
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References 13 · Cited by 32
Metadata
- Authors
- Sohn, M., Budiman‐Mak, E., Oh, E. H., Park, M. S., Stuck, R. M., Stone, N. J., & Pearce, W. B.
- Affiliations
- Northwestern University (US)
- Loyola University Medical Center (US)
- Corresponding author
- Sohn, Min‐Woong
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2012-02
- Volume
- 20
- Issue
- 2
- Pages
- 460-462
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- PMC
- PMC3978648
- OpenAlex
- W1978261100
- Cited by
- 32
- References
- 13
- Citations by year
- 2024: 4 · 2023: 2 · 2022: 6 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 5 · 2014: 1 · 2013: 3 · 2012: 1
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (T32HL094293)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Peripheral Artery Disease Management
- Keywords
- obesity paradox, lower limb amputation, diabetes mellitus, body mass index, amputation risk, amputation-free survival, veterans, diabetic men, treatment failure
- MeSH terms
- Adult, Amputation, Surgical, Diabetic Neuropathies, Follow-Up Studies, Humans, Male, Middle Aged, Obesity, Risk Factors, Veterans, Cohort Studies, Body Mass Index, Lower Extremity
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