TRPV4 mediates tumor-derived endothelial cell migration via arachidonic acid-activated actin remodeling

Fiorio Pla, A, Ong, H L, Cheng, K T, Brossa, A, Bussolati, B, Lockwich, T, Paria, B, Munaron, L +1 more·2012·Oncogene

Cited by (184)

Items 101–184 of 184

  1. Systems biology of ion channels and transporters in tumor angiogenesis: An omics view
    Luca Munaron · 2014 · Biochimica et Biophysica Acta (BBA) - Biomembranes
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    Carlos Cantonero, José Sánchez-Collado, María González-Núñez, Ginés María Salido, José Javier López, Isaac Jardín, Juan Antonio Rosado · 2019 · Cell Calcium
  3. Regulation of mitochondrial fragmentation in microvascular endothelial cells isolated from the SU5416/hypoxia model of pulmonary arterial hypertension
    Karthik S. Suresh, Laura E. Servinsky, Haiyang Jiang, Zahna Bigham, Joel Zaldumbide, John Huetsch, Corrine R. Kliment, Michelle Grace Acoba, Brian James Kirsch, Steven Michael Claypool et al. · 2019 · American Journal of Physiology-Lung Cellular and Molecular Physiology
  4. TRPV4: A trigger of pathological RhoA activation in neurological disease
    Anna M. Bagnell, Charlotte J. Sumner, Brett A. McCray · 2022 · BioEssays
  5. Mechanosensitive Ion Channels
    Jacob M. Hope, Joshua D. Greenlee, Michael R. King · 2018 · The Cancer Journal
  6. Human transient receptor potential (TRP) channel expression profiling in carcinogenesis
    Michela Bernardini, Alessandra Fiorio, Natalia B. Prevarskaya, Dimitra Gkika · 2015 · The International Journal of Developmental Biology
  7. The Role of Calcium Signaling in Regulation of Epithelial-Mesenchymal Transition
    Divya Adiga, Raghu Anekal Radhakrishnan, Sanjiban Chakrabarty, Prashant Kumar, Shama Prasada Kabekkodu · 2020 · Cells Tissues Organs
  8. Control of cell mechanics by RhoA and calcium fluxes during epithelial scattering
    Hillary Haws, Melissa A. McNeil, Marc D.H. Hansen · 2016 · Tissue Barriers
  9. Ca2+ as a therapeutic target in cancer
    Scott Gross, Pranava Mallu, Hinal Joshi, Bryant M. Schultz, Christina K. Go, Jonathan Soboloff · 2020 · Advances in cancer research
  10. Calcium signaling and epigenetics: A key point to understand carcinogenesis
    Eduardo Izquierdo‐Torres, Andrés Hernández‐Oliveras, Gabriela Fuentes-García, Ángel Zarain‐Herzberg · 2020 · Cell Calcium
  11. Mechano- and pH-sensing convergence on Ca2+-mobilising proteins – A recipe for cancer?
    Maike D. Glitsch · 2019 · Cell Calcium
  12. Activation of TRPV4 Induces Exocytosis and Ferroptosis in Human Melanoma Cells
    Mei Li, Jiaojiao Zheng, Tian Wu, Yulin He, Jing Guo, Jiao Xu, Chuanzhou Gao, Shuxian Qu, Qianyi Zhang, Jiayu Zhao et al. · 2022 · International Journal of Molecular Sciences
  13. Targeting Calcium Channels to Block Tumor Vascularization
    Luca Munaron, Tullio Genova, Daniele Avanzato, Susanna Antoniotti, Alessandra Fiorio · 2012 · Recent Patents on Anti-Cancer Drug Discovery
  14. Inhibition of TRPV4 remodels single cell polarity and suppresses the metastasis of hepatocellular carcinoma
    Jian Liu, Yongjian Guo, Ruitian Zhang, Ye Xu, Chengju Luo, Rui Wang, Shu Qing Xu, Libin Wei · 2023 · Cell Death and Disease
  15. Increasing the tumour targeting of antitumour drugs through anlotinib-mediated modulation of the extracellular matrix and the RhoA/ROCK signalling pathway
    Xuedan Han, Jialei Liu, Yidong Zhang, Eric Tse, Qiyi Yu, Lu Yu, Yi Ma, Lufeng Zheng · 2024 · Journal of Pharmaceutical Analysis
  16. Calsequestrin 2 overexpression in breast cancer increases tumorigenesis and metastasis by modulating the tumor microenvironment
    Ju Hee Kim, Eun‐Shin Lee, Jihui Yun, Han Suk Ryu, Hong Kyu Kim, Young Wook Ju, Kwangsoo Kim, Jong‐Il Kim, Hyeong‐Gon Moon · 2021 · Molecular Oncology
  17. Synergy Between Low Dose Metronomic Chemotherapy and the pH-Centered Approach Against Cancer
    Tomas Koltai, Rosa Angela Cardone, Stephan J. Reshkin · 2019 · International Journal of Molecular Sciences
  18. Calcium-Permeable Channels in Tumor Vascularization: Peculiar Sensors of Microenvironmental Chemical and Physical Cues
    Giorgia Scarpellino, Luca Munaron, Anna Rita Cantelmo, Alessandra Fiorio · 2020 · Reviews of physiology, biochemistry and pharmacology
  19. The Impact of Plasma Membrane Ion Channels on Bone Remodeling in Response to Mechanical Stress, Oxidative Imbalance, and Acidosis
    Martina Perin, Giorgia Chinigò, Tullio Genova, Federico Davide Mussano, Luca Munaron · 2023 · Antioxidants
  20. Nanoencapsulated capsaicin changes migration behavior and morphology of madin darby canine kidney cell monolayers
    Mathias Kaiser, Luisa Pohl, Steffi Ketelhut, Lena Kastl, Christian Gorzelanny, Martin Götte, Jürgen Schnekenburger, Francisco M. Goycoolea, Björn Kemper · 2017 · PLoS ONE
  21. ER Ca2+ release and store-operated Ca2+ entry – partners in crime or independent actors in oncogenic transformation?
    Cristina Pierro, Flore Sneyers, Geert Bultynck, H. Llewelyn Roderick · 2019 · Cell Calcium
  22. Identification and functional analysis of a biflavone as a novel inhibitor of transient receptor potential vanilloid 4-dependent atherogenic processes
    Mazen O. Alharbi, Bidisha Dutta, Rishov Goswami, Shweta Sharma, Kai Y Lei, Shaik O. Rahaman · 2021 · Scientific Reports
  23. Systemic lupus erythematosus, endothelial progenitor cells and intracellular Ca2+ signaling: A novel approach for an old disease
    Klara Komici, Pawan Sirwan Faris, Sharon Negri, Vittorio Rosti, Mario García‐Carrasco, Claudia Mendoza Pinto, Roberto Berra‐Romani, Ricard Cervera, Germano Guerra, Francesco Domenico Moccia · 2020 · Journal of Autoimmunity
  24. The Forces behind Directed Cell Migration
    Isabela Corina Fortunato, Raimon Sunyer · 2022 · Biophysica
  25. Mutations in calmodulin-binding domains of TRPV4/6 channels confer invasive properties to colon adenocarcinoma cells
    Atousa Arbabian, Mircea Iftinca, Christophe Altier, Param Priya Singh, Hervé Isambert, Sylvie Coscoy · 2020 · Channels
  26. Targeting Ca2+ signalling through phytomolecules to combat cancer
    Jyoti Singh, Yusuf Hussain, Suaib Luqman, Abha Meena · 2019 · Pharmacological Research
  27. Mechanical forces and metabolic changes cooperate to drive cellular memory and endothelial phenotypes
    Jin Li, Yun Hua Fang, David Wu · 2021 · Current topics in membranes
  28. Transient Receptor Potential Channels and Endothelial Cell Calcium Signaling
    Pratish Thakore, Scott Earley · 2019 · Comprehensive physiology
  29. Modulation of TRPV4 and BKCa for treatment of brain diseases
    Na Liu, Yan Fang, Qingjie Ma, Jianhua Zhao · 2020 · Bioorganic & Medicinal Chemistry
  30. Transient Receptor Potential (TRP) Channels in Tumor Vascularization
    Angelica Perna, Carmine Sellitto, Klara Komici, Eleonora Hay, Aldo Rocca, Paolo De Blasiis, Angela Lucariello, Francesco Domenico Moccia, Germano Guerra · 2022 · International Journal of Molecular Sciences
  31. Calcium channels as pharmacological targets for cancer therapy
    Xiaozhen Liu, Changyun Feng, Yan Li, Jili Cao, Xinping Zhu, Mingqian Li, Zhao Guizhi · 2025 · Clinical and Experimental Medicine
  32. The Role of the TRPV4 Channel in Intestinal Physiology and Pathology
    Dandan Liu, Mingli Mao, Wenjia Liu, Lihua Xie, Xiaolin Zhong, Wenyu Cao, Ling Chen · 2024 · Journal of Inflammation Research
  33. Calcium Signaling in Endothelial Colony Forming Cells in Health and Disease
    Francesco Domenico Moccia · 2019 · Advances in experimental medicine and biology
  34. New Insights into TRP Ion Channels in Stem Cells
    Jing Guo, Shan Chang, Jiao Xu, Mei Li, Jiayu Zhao, Wei Cheng · 2022 · International Journal of Molecular Sciences
  35. Alternative Strategies to Inhibit Tumor Vascularization
    Alessia Brossa, Lola Buono, Sofia Fallo, Alessandra Fiorio, Luca Munaron, Benedetta Bussolati · 2019 · International Journal of Molecular Sciences
  36. Transient receptor potential vanilloid (TRPV) channel expression in meningiomas: prognostic and predictive significance
    Spyridoula Goutsou, Chrisi Tsakona, Afroditi Polia, Athanasia Moutafidi, Vassiliki Zolota, George D. Gatzounis, Martha Assimakopoulou · 2019 · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
  37. Beta1-integrin and TRPV4 are involved in osteoblast adhesion to different titanium surface topographies
    Federico Davide Mussano, Tullio Genova, Marco Laurenti, Deborah Gaglioti, Giorgia Scarpellino, Paola Rivolo, Maria Giulia Faga, Alessandra Fiorio, Luca Munaron, Pietro Mandracci et al. · 2019 · Applied Surface Science
  38. Mechanosensitive TRPV4 channel guides maturation and organization of the bilayered mammary epithelium
    Tytti Kärki, Sanna Koskimäki, Carla Guenther, Pirhonen Jonatan, Eeva Kaisa Rajakylä, Tojkander Sari · 2024 · Scientific Reports
  39. Dynamic Expression of Transient Receptor Potential Vanilloid-3 and Integrated Signaling with Growth Factor Pathways during Lung Epithelial Wound Repair following Wood Smoke Particle and Other Forms of Lung Cell Injury
    Katherine L. Burrell, Nam D. Nguyen, Cassandra E. Deering‐Rice, Tosifa A. Memon, Marysol Almestica-Roberts, Emmanuel Rapp, Samantha N. Serna, John G. Lamb, Christopher A. Reilly · 2021 · Molecular Pharmacology
  40. The role of ion channels in the relationship between the immune system and cancer
    Mümin Alper Erdoğan, D’Amora Ugo, Ines Fasolino · 2023 · Current topics in membranes
  41. Transient receptor potential vanilloid type 4 (TRPV4) promotes tumorigenesis via NFAT4 activation in nasopharyngeal carcinoma
    Peng Zhang, Ke Li, Zhen Wang, Yongjin Wu, Hua Zhang, Fang Ma, Xiaoyu Liu, Michael C. F. Tong, Xiaochen Ru, Xiangmin Zhang et al. · 2022 · Frontiers in Molecular Biosciences
  42. Anti-angiogenesis effect of trichosanthin and the underlying mechanism
    Dongxu He, Jian Jin, Yong‐Tang Zheng, Iain C. Bruce, Siucheung Tam, Xin Ma · 2012 · Biochemical and Biophysical Research Communications
  43. Protein Lipidation As a Regulator of Apoptotic Calcium Release: Relevance to Cancer
    Jessica Jie Chen, Darren F. Boehning · 2017 · Frontiers in Oncology
  44. Transient Receptor Potential Vanilloid 4: a Double-Edged Sword in the Central Nervous System
    Mengliu Zeng, Shuo Kong, Tao-Xiang Chen, Biwen Peng · 2022 · Molecular Neurobiology
  45. New frontiers in the design and discovery of therapeutics that target calcium ion signaling: a novel approach in the fight against cancer
    Jyoti Singh, Abha Meena, Suaib Luqman · 2023 · Expert Opinion on Drug Discovery
  46. Vasopressin regulation of maternal body fluid balance in pregnancy and lactation: A role for TRPV channels?
    Emily F. Brown, Martin Fronius, Colin H. Brown · 2022 · Molecular and Cellular Endocrinology
  47. Involvement of TRPV1 and TRPV4 Channels in Enhancement of Metastatic Ability Induced by γ-Irradiation in Human Lung Cancer A549 Cells
    Kurumi Washiya, Rie Sasaki, Yuto Nakanishi, Kazuki Kitabatake, Keisuke Nishino, Sei‐ichi Tanuma, Shuji Kojima, Mitsutoshi Tsukimoto · 2020 · BPB Reports
  48. Neurocellular Stress Response to Mojave Type A Rattlesnake Venom: Study of Molecular Mechanisms Using Human iPSC-Derived Neural Stem Cell Model
    Kumar, Satish, Aceves, Miriam, Granados, Jose, Guerra, Lorena, Juarez, Felicia, Novilla, Earl, C. Leandro, Ana, Leandro, Marcelo, Peralta, Juan, Williams-Blangero, Sarah et al. · 2025 · Biomolecules
  49. TRP channels at the crossroads of metabolism and immunity: ion–metabolite coupling in inflammation and disease
    Liao De-hua, Shilong Jiang, Ting Wu, Zeng Cao, Zewu Zhu, Nayiyuan Wu, Xiu Zhang, Minghui Long, Jing Wang, Zhibin Wang · 2025 · Metabolism
  50. TRP channels and breast cancer: the role of TRPs in the pathophysiological development
    Yu Zhang, Yanfeng Yi, Yinghao Shu, Xiaochen Ru, Shuaibing He · 2025 · Frontiers in Molecular Biosciences
  51. A TRP to Pathological Angiogenesis and Vascular Normalization
    Venkatesh Katari, Kesha K. Dalal, Ravi Kumar Adapala, Brianna D. Guarino, Narendra Babu Kondapalli, Sailaja M. Paruchuri, Charles Kumar Thodeti · 2024 · Comprehensive physiology
  52. Breast Cancer Proteome Takes More Than Two to Tango on TRAIL: Beat Them at Their Own Game
    Ammad Ahmad Farooqı, Sundas Fayyaz, Muhammad Naeem Tahir, Muhammed Javed Iqbal, Shahzad Bhatti · 2012 · The Journal of Membrane Biology
  53. Contribution and Regulation of Calcium Channels in Endothelial Cells
    Kwong Tai Cheng, Avia Rosenhouse‐Dantsker, Asrar B. Malik · 2016 · Springer eBooks
  54. A TRP to Pathological Angiogenesis and Vascular Normalization
    Venkatesh Katari, Kesha K. Dalal, Ravi Kumar Adapala, Brianna D. Guarino, Narendra Babu Kondapalli, Sailaja M. Paruchuri, Charles Kumar Thodeti · 2024 · Comprehensive physiology
  55. Multiscale model of tumor-derived capillary-like network formation
    Marco Scianna, Luca Munaron · 2011 · Networks and Heterogeneous Media
  56. TRPV4 in Cerebral Small Vessel Disease: A key interacting partner
    Sara M.P. Lambrichts, Robert J. van Oostenbrugge, Sébastien Foulquier · 2025 · Vascular Pharmacology
  57. Reprint of: Mechanosensitive ion channels in cell migration
    Brenda Canales Coutiño, Roberto Mayor · 2021 · Cells and Development
  58. The Roles of Transient Receptor Potential (TRP) Channels Underlying Aberrant Calcium Signaling in Blood–Retinal Barrier Dysfunction
    Silvia Dragoni, Francesco Domenico Moccia, Martin D. Bootman · 2024 · Cold Spring Harbor Perspectives in Biology
  59. The potential of TRP channels as new prognostic and therapeutic targets against prostate cancer progression
    Giorgia Chinigò, Federico Alessandro Ruffinatti, Luca Munaron · 2024 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  60. 20 nm nanoparticles trigger calcium influx to endothelial cells via a TRPV4 channel
    Jaspreet Singh Nagi, Amber L. Doiron · 2025 · Biomaterials Science
  61. A high-throughput microfluidic device for probing calcium dynamics of single cells squeezing through narrow channels
    Wei-Mo Yuan, Jin‐Yu Shao, Chun‐Dong Xue, Bo Liu, Kai‐Rong Qin · 2019 · Journal of Micromechanics and Microengineering
  62. Hereditary Channelopathies Caused by TRPV4 Mutations
    Jeremy M. Sullivan, Thomas E. Lloyd, Charlotte J. Sumner · 2013 · Springer eBooks
  63. TRPV4 Orchestrates Distinct Calcium and Cell Growth Responses in Non‐Tumorigenic and Clear Cell Renal Carcinoma‐Derived Cells
    J. J. Sterba, Natalia Beltramone, Ana Beatriz Celi, Juan J. Casal, Mariel A. Fanelli, Claudia Capurro, Valeria Rivarola, Gisela Di Giusto, Paula Ford · 2025 · Journal of Cellular Physiology
  64. Transient receptor potential vanilloid channels in inflammatory bowel diseases: linking inflammation, angiogenesis, and oxidative stress
    Peihong Li, Yikun Zhang, Siqing Guo, Hongyi Hu, Tingjun Cheng, Kexin Zeng, Tingting Zhang, Linda Zhong, Jiang Lin, Boyun Sun · 2026 · Inflammopharmacology
  65. Ablation of TRPV4 in HepG2 with Its CRISPR/Cas9 Enhances Its Wound Healing
    Eun Jeoung Lee, Sung Hwa Shin, Sung Hee Hyun, Sang Sun Kang · 2020 · American Journal of Molecular Biology
  66. TRPV Family Ion Channels in the Mammary Epithelium: Role in Normal Tissue Homeostasis and along Breast Cancer Progression
    Sari Tojkander · 2022 · Biochemistry
  67. TRPV4 and the paradox of faster cellular migration rates in more viscous extracellular fluids
    Choon Leng So, Mélanie Robitaille, Gregory Raymond Monteith · 2022 · Cell Calcium
  68. TRP channel expression in the tumor microenvironment: Implications for tumor progression and metastasis
    Nuray Erin · 2024 · Elsevier eBooks
  69. Multiscale extensions of the cellular Potts models: toward a nested-hybrid approach
    Marco Scianna · 2012 · PORTO@Iris
  70. The Role of Transient Receptor Potential Vanilloid Member 4 (TRPV4) in Regulating Endothelial Integrity and Vasodilatory Mediator Release: Implications for Vascular and Pulmonary Responses.
    Christian H. James · 2014 · Surrey Research Insight Open Access (The University of Surrey)
  71. Phospholipase A and Breast Cancer
    Warren Thomas · 2014 · Springer eBooks
  72. TRPV4 channel regulation and involvement in cell motility
    Sanela Mrkonjić · 2014 · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
  73. Remodelado del Ca2+ Intracelular en el cáncer colorrectal: descripción, bases moleculares y consecuencias funcionales
    Diego Sobradillo Luengo · 2015
  74. Components of Intracellular Calcium Movements in Cancer Cells: Review
    Leman Yalçıntepe · 2017 · Turkiye Klinikleri Journal of Medical Sciences
  75. Ion Channels in Cancer
    Mohammad Ashrafuzzaman · 2018 · Springer eBooks
  76. Calcium signalling modifying proteins as targets for breast cancer therapy
    Siti Yusrina Nadihah Jamaludin · 2014 · The University of Queensland
  77. Faculty Opinions recommendation of Endothelial TRPV4 channels modulate vascular tone by Ca2+ -induced Ca2+ release at inositol 1,4,5-trisphosphate receptors.
    Anne McLaren Dorrance · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  78. Finding a link between the TRPV4 ion channel and angiogenesis: a potential therapeutic target for vascular remodeling
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  79. Etude des mécanismes cellulaires de l'hypertension artérielle pulmonaire : rôle des canaux TRPV dans l'hyperréactivité et le remodelage des artères pulmonaires de rat
    Diana Dahan · 2011
  80. Rôle et régulation du canal TRPM8 dans la progression et la dissémination métastatique du cancer de la prostate
    Guillaume Paul Grolez · 2018
  81. L'interaction entre le canal calcique Orai3 et la protéine réticulaire STIM2 contribue à la prolifération et la survie des cellules cancéreuses prostatiques
    Sana Kouba · 2020 · theses.fr (ABES)
  82. Caractérisation des récepteurs de l'inositol (1,4,5) trisphosphate dans le cancer mammaire humain invasif : nouvel outil diagnostique et pronostique?
    Arthur Foulon · 2020 · theses.fr (ABES)
  83. TRP channels functional role in prostate cancer angiogenesis and invasion
    Giorgia Chinigò · 2022
  84. BindingDB Entry 50012770: Modulation of TRPV4 and BKCa for treatment of brain diseases.
    BindingDB · 2022 · UC San Diego