TRPV4 mediates tumor-derived endothelial cell migration via arachidonic acid-activated actin remodeling
Fiorio Pla, A, Ong, H L, Cheng, K T, Brossa, A, Bussolati, B, Lockwich, T, Paria, B, Munaron, L +1 more·2012·Oncogene
Cited by (184)
Items 101–184 of 184
- Systems biology of ion channels and transporters in tumor angiogenesis: An omics viewLuca Munaron · 2014 · Biochimica et Biophysica Acta (BBA) - Biomembranes
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- Regulation of mitochondrial fragmentation in microvascular endothelial cells isolated from the SU5416/hypoxia model of pulmonary arterial hypertensionKarthik S. Suresh, Laura E. Servinsky, Haiyang Jiang, Zahna Bigham, Joel Zaldumbide, John Huetsch, Corrine R. Kliment, Michelle Grace Acoba, Brian James Kirsch, Steven Michael Claypool et al. · 2019 · American Journal of Physiology-Lung Cellular and Molecular Physiology
- TRPV4: A trigger of pathological RhoA activation in neurological diseaseAnna M. Bagnell, Charlotte J. Sumner, Brett A. McCray · 2022 · BioEssays
- Mechanosensitive Ion ChannelsJacob M. Hope, Joshua D. Greenlee, Michael R. King · 2018 · The Cancer Journal
- Human transient receptor potential (TRP) channel expression profiling in carcinogenesisMichela Bernardini, Alessandra Fiorio, Natalia B. Prevarskaya, Dimitra Gkika · 2015 · The International Journal of Developmental Biology
- The Role of Calcium Signaling in Regulation of Epithelial-Mesenchymal TransitionDivya Adiga, Raghu Anekal Radhakrishnan, Sanjiban Chakrabarty, Prashant Kumar, Shama Prasada Kabekkodu · 2020 · Cells Tissues Organs
- Control of cell mechanics by RhoA and calcium fluxes during epithelial scatteringHillary Haws, Melissa A. McNeil, Marc D.H. Hansen · 2016 · Tissue Barriers
- Ca2+ as a therapeutic target in cancerScott Gross, Pranava Mallu, Hinal Joshi, Bryant M. Schultz, Christina K. Go, Jonathan Soboloff · 2020 · Advances in cancer research
- Calcium signaling and epigenetics: A key point to understand carcinogenesisEduardo Izquierdo‐Torres, Andrés Hernández‐Oliveras, Gabriela Fuentes-García, Ángel Zarain‐Herzberg · 2020 · Cell Calcium
- Mechano- and pH-sensing convergence on Ca2+-mobilising proteins – A recipe for cancer?Maike D. Glitsch · 2019 · Cell Calcium
- Activation of TRPV4 Induces Exocytosis and Ferroptosis in Human Melanoma CellsMei Li, Jiaojiao Zheng, Tian Wu, Yulin He, Jing Guo, Jiao Xu, Chuanzhou Gao, Shuxian Qu, Qianyi Zhang, Jiayu Zhao et al. · 2022 · International Journal of Molecular Sciences
- Targeting Calcium Channels to Block Tumor VascularizationLuca Munaron, Tullio Genova, Daniele Avanzato, Susanna Antoniotti, Alessandra Fiorio · 2012 · Recent Patents on Anti-Cancer Drug Discovery
- Inhibition of TRPV4 remodels single cell polarity and suppresses the metastasis of hepatocellular carcinomaJian Liu, Yongjian Guo, Ruitian Zhang, Ye Xu, Chengju Luo, Rui Wang, Shu Qing Xu, Libin Wei · 2023 · Cell Death and Disease
- Increasing the tumour targeting of antitumour drugs through anlotinib-mediated modulation of the extracellular matrix and the RhoA/ROCK signalling pathwayXuedan Han, Jialei Liu, Yidong Zhang, Eric Tse, Qiyi Yu, Lu Yu, Yi Ma, Lufeng Zheng · 2024 · Journal of Pharmaceutical Analysis
- Calsequestrin 2 overexpression in breast cancer increases tumorigenesis and metastasis by modulating the tumor microenvironmentJu Hee Kim, Eun‐Shin Lee, Jihui Yun, Han Suk Ryu, Hong Kyu Kim, Young Wook Ju, Kwangsoo Kim, Jong‐Il Kim, Hyeong‐Gon Moon · 2021 · Molecular Oncology
- Synergy Between Low Dose Metronomic Chemotherapy and the pH-Centered Approach Against CancerTomas Koltai, Rosa Angela Cardone, Stephan J. Reshkin · 2019 · International Journal of Molecular Sciences
- Calcium-Permeable Channels in Tumor Vascularization: Peculiar Sensors of Microenvironmental Chemical and Physical CuesGiorgia Scarpellino, Luca Munaron, Anna Rita Cantelmo, Alessandra Fiorio · 2020 · Reviews of physiology, biochemistry and pharmacology
- The Impact of Plasma Membrane Ion Channels on Bone Remodeling in Response to Mechanical Stress, Oxidative Imbalance, and AcidosisMartina Perin, Giorgia Chinigò, Tullio Genova, Federico Davide Mussano, Luca Munaron · 2023 · Antioxidants
- Nanoencapsulated capsaicin changes migration behavior and morphology of madin darby canine kidney cell monolayersMathias Kaiser, Luisa Pohl, Steffi Ketelhut, Lena Kastl, Christian Gorzelanny, Martin Götte, Jürgen Schnekenburger, Francisco M. Goycoolea, Björn Kemper · 2017 · PLoS ONE
- ER Ca2+ release and store-operated Ca2+ entry – partners in crime or independent actors in oncogenic transformation?Cristina Pierro, Flore Sneyers, Geert Bultynck, H. Llewelyn Roderick · 2019 · Cell Calcium
- Identification and functional analysis of a biflavone as a novel inhibitor of transient receptor potential vanilloid 4-dependent atherogenic processesMazen O. Alharbi, Bidisha Dutta, Rishov Goswami, Shweta Sharma, Kai Y Lei, Shaik O. Rahaman · 2021 · Scientific Reports
- Systemic lupus erythematosus, endothelial progenitor cells and intracellular Ca2+ signaling: A novel approach for an old diseaseKlara Komici, Pawan Sirwan Faris, Sharon Negri, Vittorio Rosti, Mario García‐Carrasco, Claudia Mendoza Pinto, Roberto Berra‐Romani, Ricard Cervera, Germano Guerra, Francesco Domenico Moccia · 2020 · Journal of Autoimmunity
- The Forces behind Directed Cell MigrationIsabela Corina Fortunato, Raimon Sunyer · 2022 · Biophysica
- Mutations in calmodulin-binding domains of TRPV4/6 channels confer invasive properties to colon adenocarcinoma cellsAtousa Arbabian, Mircea Iftinca, Christophe Altier, Param Priya Singh, Hervé Isambert, Sylvie Coscoy · 2020 · Channels
- Targeting Ca2+ signalling through phytomolecules to combat cancerJyoti Singh, Yusuf Hussain, Suaib Luqman, Abha Meena · 2019 · Pharmacological Research
- Mechanical forces and metabolic changes cooperate to drive cellular memory and endothelial phenotypesJin Li, Yun Hua Fang, David Wu · 2021 · Current topics in membranes
- Transient Receptor Potential Channels and Endothelial Cell Calcium SignalingPratish Thakore, Scott Earley · 2019 · Comprehensive physiology
- Modulation of TRPV4 and BKCa for treatment of brain diseasesNa Liu, Yan Fang, Qingjie Ma, Jianhua Zhao · 2020 · Bioorganic & Medicinal Chemistry
- Transient Receptor Potential (TRP) Channels in Tumor VascularizationAngelica Perna, Carmine Sellitto, Klara Komici, Eleonora Hay, Aldo Rocca, Paolo De Blasiis, Angela Lucariello, Francesco Domenico Moccia, Germano Guerra · 2022 · International Journal of Molecular Sciences
- Calcium channels as pharmacological targets for cancer therapyXiaozhen Liu, Changyun Feng, Yan Li, Jili Cao, Xinping Zhu, Mingqian Li, Zhao Guizhi · 2025 · Clinical and Experimental Medicine
- The Role of the TRPV4 Channel in Intestinal Physiology and PathologyDandan Liu, Mingli Mao, Wenjia Liu, Lihua Xie, Xiaolin Zhong, Wenyu Cao, Ling Chen · 2024 · Journal of Inflammation Research
- Calcium Signaling in Endothelial Colony Forming Cells in Health and DiseaseFrancesco Domenico Moccia · 2019 · Advances in experimental medicine and biology
- New Insights into TRP Ion Channels in Stem CellsJing Guo, Shan Chang, Jiao Xu, Mei Li, Jiayu Zhao, Wei Cheng · 2022 · International Journal of Molecular Sciences
- Alternative Strategies to Inhibit Tumor VascularizationAlessia Brossa, Lola Buono, Sofia Fallo, Alessandra Fiorio, Luca Munaron, Benedetta Bussolati · 2019 · International Journal of Molecular Sciences
- Transient receptor potential vanilloid (TRPV) channel expression in meningiomas: prognostic and predictive significanceSpyridoula Goutsou, Chrisi Tsakona, Afroditi Polia, Athanasia Moutafidi, Vassiliki Zolota, George D. Gatzounis, Martha Assimakopoulou · 2019 · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
- Beta1-integrin and TRPV4 are involved in osteoblast adhesion to different titanium surface topographiesFederico Davide Mussano, Tullio Genova, Marco Laurenti, Deborah Gaglioti, Giorgia Scarpellino, Paola Rivolo, Maria Giulia Faga, Alessandra Fiorio, Luca Munaron, Pietro Mandracci et al. · 2019 · Applied Surface Science
- Mechanosensitive TRPV4 channel guides maturation and organization of the bilayered mammary epitheliumTytti Kärki, Sanna Koskimäki, Carla Guenther, Pirhonen Jonatan, Eeva Kaisa Rajakylä, Tojkander Sari · 2024 · Scientific Reports
- Dynamic Expression of Transient Receptor Potential Vanilloid-3 and Integrated Signaling with Growth Factor Pathways during Lung Epithelial Wound Repair following Wood Smoke Particle and Other Forms of Lung Cell InjuryKatherine L. Burrell, Nam D. Nguyen, Cassandra E. Deering‐Rice, Tosifa A. Memon, Marysol Almestica-Roberts, Emmanuel Rapp, Samantha N. Serna, John G. Lamb, Christopher A. Reilly · 2021 · Molecular Pharmacology
- The role of ion channels in the relationship between the immune system and cancerMümin Alper Erdoğan, D’Amora Ugo, Ines Fasolino · 2023 · Current topics in membranes
- Transient receptor potential vanilloid type 4 (TRPV4) promotes tumorigenesis via NFAT4 activation in nasopharyngeal carcinomaPeng Zhang, Ke Li, Zhen Wang, Yongjin Wu, Hua Zhang, Fang Ma, Xiaoyu Liu, Michael C. F. Tong, Xiaochen Ru, Xiangmin Zhang et al. · 2022 · Frontiers in Molecular Biosciences
- Anti-angiogenesis effect of trichosanthin and the underlying mechanismDongxu He, Jian Jin, Yong‐Tang Zheng, Iain C. Bruce, Siucheung Tam, Xin Ma · 2012 · Biochemical and Biophysical Research Communications
- Protein Lipidation As a Regulator of Apoptotic Calcium Release: Relevance to CancerJessica Jie Chen, Darren F. Boehning · 2017 · Frontiers in Oncology
- Transient Receptor Potential Vanilloid 4: a Double-Edged Sword in the Central Nervous SystemMengliu Zeng, Shuo Kong, Tao-Xiang Chen, Biwen Peng · 2022 · Molecular Neurobiology
- New frontiers in the design and discovery of therapeutics that target calcium ion signaling: a novel approach in the fight against cancerJyoti Singh, Abha Meena, Suaib Luqman · 2023 · Expert Opinion on Drug Discovery
- Vasopressin regulation of maternal body fluid balance in pregnancy and lactation: A role for TRPV channels?Emily F. Brown, Martin Fronius, Colin H. Brown · 2022 · Molecular and Cellular Endocrinology
- Involvement of TRPV1 and TRPV4 Channels in Enhancement of Metastatic Ability Induced by γ-Irradiation in Human Lung Cancer A549 CellsKurumi Washiya, Rie Sasaki, Yuto Nakanishi, Kazuki Kitabatake, Keisuke Nishino, Sei‐ichi Tanuma, Shuji Kojima, Mitsutoshi Tsukimoto · 2020 · BPB Reports
- Neurocellular Stress Response to Mojave Type A Rattlesnake Venom: Study of Molecular Mechanisms Using Human iPSC-Derived Neural Stem Cell ModelKumar, Satish, Aceves, Miriam, Granados, Jose, Guerra, Lorena, Juarez, Felicia, Novilla, Earl, C. Leandro, Ana, Leandro, Marcelo, Peralta, Juan, Williams-Blangero, Sarah et al. · 2025 · Biomolecules
- TRP channels at the crossroads of metabolism and immunity: ion–metabolite coupling in inflammation and diseaseLiao De-hua, Shilong Jiang, Ting Wu, Zeng Cao, Zewu Zhu, Nayiyuan Wu, Xiu Zhang, Minghui Long, Jing Wang, Zhibin Wang · 2025 · Metabolism
- TRP channels and breast cancer: the role of TRPs in the pathophysiological developmentYu Zhang, Yanfeng Yi, Yinghao Shu, Xiaochen Ru, Shuaibing He · 2025 · Frontiers in Molecular Biosciences
- A TRP to Pathological Angiogenesis and Vascular NormalizationVenkatesh Katari, Kesha K. Dalal, Ravi Kumar Adapala, Brianna D. Guarino, Narendra Babu Kondapalli, Sailaja M. Paruchuri, Charles Kumar Thodeti · 2024 · Comprehensive physiology
- Breast Cancer Proteome Takes More Than Two to Tango on TRAIL: Beat Them at Their Own GameAmmad Ahmad Farooqı, Sundas Fayyaz, Muhammad Naeem Tahir, Muhammed Javed Iqbal, Shahzad Bhatti · 2012 · The Journal of Membrane Biology
- Contribution and Regulation of Calcium Channels in Endothelial CellsKwong Tai Cheng, Avia Rosenhouse‐Dantsker, Asrar B. Malik · 2016 · Springer eBooks
- A TRP to Pathological Angiogenesis and Vascular NormalizationVenkatesh Katari, Kesha K. Dalal, Ravi Kumar Adapala, Brianna D. Guarino, Narendra Babu Kondapalli, Sailaja M. Paruchuri, Charles Kumar Thodeti · 2024 · Comprehensive physiology
- Multiscale model of tumor-derived capillary-like network formationMarco Scianna, Luca Munaron · 2011 · Networks and Heterogeneous Media
- TRPV4 in Cerebral Small Vessel Disease: A key interacting partnerSara M.P. Lambrichts, Robert J. van Oostenbrugge, Sébastien Foulquier · 2025 · Vascular Pharmacology
- Reprint of: Mechanosensitive ion channels in cell migrationBrenda Canales Coutiño, Roberto Mayor · 2021 · Cells and Development
- The Roles of Transient Receptor Potential (TRP) Channels Underlying Aberrant Calcium Signaling in Blood–Retinal Barrier DysfunctionSilvia Dragoni, Francesco Domenico Moccia, Martin D. Bootman · 2024 · Cold Spring Harbor Perspectives in Biology
- The potential of TRP channels as new prognostic and therapeutic targets against prostate cancer progressionGiorgia Chinigò, Federico Alessandro Ruffinatti, Luca Munaron · 2024 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- 20 nm nanoparticles trigger calcium influx to endothelial cells via a TRPV4 channelJaspreet Singh Nagi, Amber L. Doiron · 2025 · Biomaterials Science
- A high-throughput microfluidic device for probing calcium dynamics of single cells squeezing through narrow channelsWei-Mo Yuan, Jin‐Yu Shao, Chun‐Dong Xue, Bo Liu, Kai‐Rong Qin · 2019 · Journal of Micromechanics and Microengineering
- Hereditary Channelopathies Caused by TRPV4 MutationsJeremy M. Sullivan, Thomas E. Lloyd, Charlotte J. Sumner · 2013 · Springer eBooks
- TRPV4 Orchestrates Distinct Calcium and Cell Growth Responses in Non‐Tumorigenic and Clear Cell Renal Carcinoma‐Derived CellsJ. J. Sterba, Natalia Beltramone, Ana Beatriz Celi, Juan J. Casal, Mariel A. Fanelli, Claudia Capurro, Valeria Rivarola, Gisela Di Giusto, Paula Ford · 2025 · Journal of Cellular Physiology
- Transient receptor potential vanilloid channels in inflammatory bowel diseases: linking inflammation, angiogenesis, and oxidative stressPeihong Li, Yikun Zhang, Siqing Guo, Hongyi Hu, Tingjun Cheng, Kexin Zeng, Tingting Zhang, Linda Zhong, Jiang Lin, Boyun Sun · 2026 · Inflammopharmacology
- Ablation of TRPV4 in HepG2 with Its CRISPR/Cas9 Enhances Its Wound HealingEun Jeoung Lee, Sung Hwa Shin, Sung Hee Hyun, Sang Sun Kang · 2020 · American Journal of Molecular Biology
- TRPV Family Ion Channels in the Mammary Epithelium: Role in Normal Tissue Homeostasis and along Breast Cancer ProgressionSari Tojkander · 2022 · Biochemistry
- TRPV4 and the paradox of faster cellular migration rates in more viscous extracellular fluidsChoon Leng So, Mélanie Robitaille, Gregory Raymond Monteith · 2022 · Cell Calcium
- TRP channel expression in the tumor microenvironment: Implications for tumor progression and metastasisNuray Erin · 2024 · Elsevier eBooks
- Multiscale extensions of the cellular Potts models: toward a nested-hybrid approachMarco Scianna · 2012 · PORTO@Iris
- The Role of Transient Receptor Potential Vanilloid Member 4 (TRPV4) in Regulating Endothelial Integrity and Vasodilatory Mediator Release: Implications for Vascular and Pulmonary Responses.Christian H. James · 2014 · Surrey Research Insight Open Access (The University of Surrey)
- Phospholipase A and Breast CancerWarren Thomas · 2014 · Springer eBooks
- TRPV4 channel regulation and involvement in cell motilitySanela Mrkonjić · 2014 · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
- Remodelado del Ca2+ Intracelular en el cáncer colorrectal: descripción, bases moleculares y consecuencias funcionalesDiego Sobradillo Luengo · 2015
- Components of Intracellular Calcium Movements in Cancer Cells: ReviewLeman Yalçıntepe · 2017 · Turkiye Klinikleri Journal of Medical Sciences
- Ion Channels in CancerMohammad Ashrafuzzaman · 2018 · Springer eBooks
- Calcium signalling modifying proteins as targets for breast cancer therapySiti Yusrina Nadihah Jamaludin · 2014 · The University of Queensland
- Faculty Opinions recommendation of Endothelial TRPV4 channels modulate vascular tone by Ca2+ -induced Ca2+ release at inositol 1,4,5-trisphosphate receptors.Anne McLaren Dorrance · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Finding a link between the TRPV4 ion channel and angiogenesis: a potential therapeutic target for vascular remodelingGabriel Malka, Vanessa Salucci, Andreas Bergdahl · 2025 · Canadian Journal of Physiology and Pharmacology
- Etude des mécanismes cellulaires de l'hypertension artérielle pulmonaire : rôle des canaux TRPV dans l'hyperréactivité et le remodelage des artères pulmonaires de ratDiana Dahan · 2011
- Rôle et régulation du canal TRPM8 dans la progression et la dissémination métastatique du cancer de la prostateGuillaume Paul Grolez · 2018
- L'interaction entre le canal calcique Orai3 et la protéine réticulaire STIM2 contribue à la prolifération et la survie des cellules cancéreuses prostatiquesSana Kouba · 2020 · theses.fr (ABES)
- Caractérisation des récepteurs de l'inositol (1,4,5) trisphosphate dans le cancer mammaire humain invasif : nouvel outil diagnostique et pronostique?Arthur Foulon · 2020 · theses.fr (ABES)
- TRP channels functional role in prostate cancer angiogenesis and invasionGiorgia Chinigò · 2022
- BindingDB Entry 50012770: Modulation of TRPV4 and BKCa for treatment of brain diseases.BindingDB · 2022 · UC San Diego