Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas
Wang, P, Dong, Q, Zhang, C, Kuan, P-F, Liu, Y, Jeck, W R, Andersen, J B, Jiang, W +18 more·2013·Oncogene
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Mutation Subgroup Status Associates with Intratumor Heterogeneity and the Tumor Microenvironment in Intrahepatic CholangiocarcinomaXiang, Xiao, Liu, Ziyang, Zhang, Chong, Li, Zhao, Gao, Jie, Zhang, Changkun, Cao, Qi, Cheng, Jinghui, Liu, Hengkang, Chen, Dingbao et al. · 2021 · Advanced Science
- IDH1 or -2 mutations do not predict outcome and do not cause loss of 5-hydroxymethylcytosine or altered histone modifications in central chondrosarcomasArjen H.G. Cleven, Johnny Suijker, Georgios Agrogiannis, Inge H. Briaire‐de Bruijn, Norma Frizzell, Attje S. Hoekstra, Pauline M. Wijers‐Koster, Anne‐Marie Cleton-Jansen, Judith V.M.G. Bovée · 2017 · Clinical Sarcoma Research
- Intrahepatic cholangiocarcinoma: current management and emerging therapiesAmir Ata Rahnemai‐Azar, Allison B. Weisbrod, Mary E. Dillhoff, Carl Richard Schmidt, Timothy Michael Pawlik · 2017 · Expert Review of Gastroenterology & Hepatology
- A cfDNA methylation-based tissue-of-origin classifier for cancers of unknown primaryAlicia‐Marie Conway, Simon P. Pearce, Alexandra Clipson, Steven M. Hill, Francesca Chemi, Daniel Slane-Tan, Saba Ferdous, Arman Hossain, Katarzyna Kamieniecka, Daniel J. White et al. · 2024 · Nature Communications
- Specific monoclonal antibodies against IDH1/2 mutations as diagnostic tools for gliomasYukinari Kato · 2014 · Brain Tumor Pathology
- Isocitrate dehydrogenase variants in cancer — Cellular consequences and therapeutic opportunitiesShuang Liu, Tom A.D. Cadoux-Hudson, Christopher John Schofield · 2020 · Current Opinion in Chemical Biology
- Mitogen-Activated Protein Kinases (MAPKs) and Cholangiocarcinoma: The Missing LinkChaobo Chen, Leonard J. Nelson, Matias Antonio Avila, Francisco Javier Cubero · 2019 · Cells
- Molecular pathogenesis of intrahepatic cholangiocarcinomaJesper Bøje Andersen · 2014 · Journal of Hepato-Biliary-Pancreatic Sciences
- Global DNA methylation and hydroxymethylation differ in hepatocellular carcinoma and cholangiocarcinoma and relate to survival rateSilvia Udali, Patrizia Guarini, Sara Moruzzi, Andrea Ruzzenente, Stephanie A. Tammen, Alfredo Guglielmi, Simone Conci, Patrizia Pattini, Oliviero Olivieri, Roberto Corrocher et al. · 2015 · Hepatology
- Biliary cancer: intrahepatic cholangiocarcinoma vs. extrahepatic cholangiocarcinoma vs. gallbladder cancers: classification and therapeutic implicationsDaniel H. Ahn, Tanios Bekaii‐Saab · 2017 · Journal of Gastrointestinal Oncology
- IDH Mutations in Tumorigenesis and Their Potential Role As Novel Therapeutic TargetsDaniel Krell, Paul James Mulholland, Adam Enver Frampton, Jonathan Krell, Justin Stebbing, Chiara Bardella · 2013 · Future Oncology
- Cell-free DNA from bile outperformed plasma as a potential alternative to tissue biopsy in biliary tract cancerQing Gou, C.Z. Zhang, Zhanguo Sun, Lei Wu, Y. Chen, Zhanjie Mo, Qicong Mai, Jian He, Zhigang Zhou, F. Shi et al. · 2021 · ESMO Open
- Cholangiocarcinoma: risk factors, environmental influences and oncogenesis.Redha Al-Bahrani, Yasser Abuetabh, Nikolas Zeitouni, Consolato Maria Sergi · 2013 · PubMed
- New developments in systemic therapy for advanced biliary tract cancerChigusa Morizane, Makoto Ueno, Masafumi Ikeda, Takuji Okusaka, Hiroshi Ishii, Junji Furuse · 2018 · Japanese Journal of Clinical Oncology
- SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumorsXiaomin Wang, Ziqi Chen, Jun Xu, Shuai Tang, Nan An, Lei Jiang, Yixiang Zhang, Shaoying Zhang, Qingli Zhang, Yanyan Shen et al. · 2022 · Cell Research
- The potential role of comprehensive genomic profiling to guide targeted therapy for patients with biliary cancerHwajeong Lee, Jeffrey S. Ross · 2017 · Therapeutic Advances in Gastroenterology
- Genetics of Opisthorchis viverrini-related cholangiocarcinomaApinya Jusakul, Sarinya Kongpetch, Bin Tean Teh · 2015 · Current Opinion in Gastroenterology
- Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotypeElisabet Cuyàs, Salvador Fernández‐Arroyo, Bruna Corominas-Faja, Esther Rodríguez‐Gallego, Joaquim Bosch‐Barrera, Begoña Martı́n-Castillo, Rafel Llorens, Jorge Joven, Javier Abel Menéndez · 2015 · Oncotarget
- Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KGAnna Catharina Navis, Simone P. Niclou, Fred Fack, Daniel Stieber, Sanne A. M. van Lith, Kiek N. Verrijp, Alan J. Wright, Jonathan Stauber, Bastiaan B.J. Tops, Irene Otte‐Höller et al. · 2013 · Acta Neuropathologica Communications
- High-throughput mutation profiling identifies novel molecular dysregulation in high-grade intraepithelial neoplasia and early gastric cancersMatteo Fassan, Michele Simbolo, Emilio Bria, Andrea Mafficini, Sara Pilotto, Paola Capelli, Maria Bencivenga, Sara Pecori, Claudio Luchini, Diogo Neves et al. · 2013 · Gastric Cancer
- Fibroblast growth factor receptor 2 fusions as a target for treating cholangiocarcinomaMitesh J. Borad, Gregory James Gores, Lewis Rowland Roberts · 2015 · Current Opinion in Gastroenterology
- 5-Hydroxymethylcytosine Profiling as an Indicator of Cellular StateAlexander Laird, John P. Thomson, David James Harrison, Richard R. Meehan · 2013 · Epigenomics
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- Mutant IDH in Gliomas: Role in Cancer and Treatment OptionsGeorgios Solomou, Alina Finch, Asim Asghar, Chiara Bardella · 2023 · Cancers
- Molecular docking and molecular dynamics studies reveal structural basis of inhibition and selectivity of inhibitors EGCG and OSU-03012 toward glucose regulated protein-78 (GRP78) overexpressed in glioblastomaRituparna Bhattacharjee, Arpita Devi, Seema Mishra · 2015 · Journal of Molecular Modeling
- D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growthShenghong Ma, Bowen Jiang, Wanglong Deng, Zhong-Kai Gu, Fei-Zhen Wu, Tingting Li, Yukun Xia, Hui Yang, Dan Ye, Yue Xiong et al. · 2015 · Oncotarget
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- Mutations of isocitrate dehydrogenase 1 and 2 in intrahepatic cholangiocarcinomaAlexandra R. Grassian, Raymond A. Pagliarini, Derek Y. Chiang · 2014 · Current Opinion in Gastroenterology
- The immune milieu of cholangiocarcinoma: From molecular pathogenesis to precision medicineLorenza Rimassa, Nicola Personeni, Alessio Aghemo, Ana Lleò · 2019 · Journal of Autoimmunity
- Driver mutations of intrahepatic cholangiocarcinoma shape clinically relevant genomic clusters with distinct molecular features and therapeutic vulnerabilitiesXiangyu Wang, Wenwei Zhu, Zheng Wang, Jian-Bo Huang, Shenghao Wang, Fumao Bai, Tian‐En Li, Ying Zhu, Jing Zhao, Xin Yang et al. · 2021 · Theranostics
- IDH1, a CHOP and C/EBPβ-responsive gene under ER stress, sensitizes human melanoma cells to hypoxia-induced apoptosisXuejun Yang, Tongde Du, Xiang Wang, Yingqiu Zhang, Wanglai Hu, Xiaofeng Du, Lin Miao, Chuanchun Han · 2015 · Cancer Letters
- Proximity ligation assay evaluates IDH1R132H presentation in gliomasLukas Bunse, Theresa Schumacher, Felix Sahm, Stefan Pusch, Iris Oezen, Katharina J. Rauschenbach, Marina Gonzalez, Gergely Morten Solecki, Matthias Osswald, David Capper et al. · 2015 · Journal of Clinical Investigation
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- Functional and topographic effects on DNA methylation in IDH1/2 mutant cancersRamona Bledea, Varshini Vasudevaraja, Seema V. Patel, James M. Stafford, Jonathan Serrano, Gianna Esposito, Lilian M. Tredwin, Nina E. Goodman, Andreas Kloetgen, John G. Golfinos et al. · 2019 · Scientific Reports
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- Epigenome Remodeling in CholangiocarcinomaColm J. O’Rourke, Juan F. Lafuente-Barquero, Jesper Bøje Andersen · 2019 · Trends in cancer
- Molecular profiling of intrahepatic and extrahepatic cholangiocarcinoma using next generation sequencingJuan Putra, Francine Blumental De Abreu, Jason D. Peterson, J. Marc Pipas, Kabir Mody, Christopher Ian Amos, Gregory J. Tsongalis, Arief Antonius Suriawinata · 2015 · Experimental and Molecular Pathology
- Epigenome dysregulation in cholangiocarcinomaColm J. O’Rourke, Patricia Muñoz-Garrido, Esmeralda L. Aguayo, Jesper Bøje Andersen · 2017 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
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- Cholangiocarcinoma 2020: the next horizon in mechanisms and managementBanales, Jesus M., Marin, Jose J. G., Lamarca, Angela, Rodrigues, Pedro M., Khan, Shahid A., Roberts, Lewis R., Cardinale, Vincenzo, Carpino, Guido, Andersen, Jesper B., Braconi, Chiara et al. · 2020 · Nature Reviews Gastroenterology & Hepatology
- Novel targeted treatment options for advanced cholangiocarcinomaAmit Mahipal, Anuhya Kommalapati, Sri Harsha Tella, Alexander Lim, Richard D. Kim · 2018 · Expert Opinion on Investigational Drugs
- The Emerging Role of D-2-Hydroxyglutarate as an Oncometabolite in Hematolymphoid and Central Nervous System NeoplasmsDinesh Rakheja, Leonard Jeffrey Medeiros, Scott Bevan, Weina Chen · 2013 · Frontiers in Oncology
- Pathogenesis of cholangiocarcinoma: From genetics to signalling pathwaysSarinya Kongpetch, Apinya Jusakul, Choon Kiat Ong, Weng Khong Lim, Steve Rozen, Patrick B. O. Tan, Bin Tean Teh · 2015 · Best Practice & Research Clinical Gastroenterology
- Beyond Brooding on Oncometabolic Havoc in IDH-Mutant Gliomas and AML: Current and Future Therapeutic StrategiesHanumantha Rao Madala, Surendra Reddy Punganuru, Viswanath Arutla, Subhasis Misra, Thresia Thomas, Kalkunte S. Srivenugopal · 2018 · Cancers
- The oncometabolite D-2-hydroxyglutarate induced by mutant IDH1 or -2 blocks osteoblast differentiation in vitro and in vivoJohnny Suijker, Hans J. Baelde, Helene Roelofs, Anne‐Marie Cleton-Jansen, Judith V.M.G. Bovée · 2015 · Oncotarget
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- L2hgdh Deficiency Accumulates l -2-Hydroxyglutarate with Progressive Leukoencephalopathy and NeurodegenerationShenghong Ma, Renqiang Sun, Bowen Jiang, Jun Gao, Wanglong Deng, Peng Liu, Ruoyu He, Jing Cui, Minbiao Ji, Wei Yi et al. · 2017 · Molecular and Cellular Biology
- Molecular Targets in CholangiocarcinomaColm J. O’Rourke, Patricia Muñoz-Garrido, Jesper Bøje Andersen · 2020 · Hepatology
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- IDH1, lipid metabolism and cancer: Shedding new light on old ideasElena Bogdanovic · 2015 · Biochimica et Biophysica Acta (BBA) - General Subjects
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- Clinicopathological, radiologic, and molecular study of 23 combined hepatocellular-cholangiocarcinomas with stem cell features, cholangiolocellular typeJun Chen, Jian He, Min Deng, Hongyan Wu, Jiong Shi, Liang Mao, Qi Sun, Min Tang, Xiangshan Fan, Yudong Qiu et al. · 2017 · Human Pathology
- Circulating oncometabolite D-2-hydroxyglutarate enantiomer is a surrogate marker of isocitrate dehydrogenase–mutated intrahepatic cholangiocarcinomasJ Delahousse, Loïc Verlingue, Sophie Broutin, Clémence Legoupil, Mehdi Touat, Ludovic S. Doucet, Samy Ammari, Ludovic Lacroix, Michel Pierre Ducreux, Jean‐Yves Scoazec et al. · 2018 · European Journal of Cancer
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