The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.
mTORC1 and mTORC2 in cancer and the tumor microenvironment
Open accessAbstract
The mammalian target of rapamycin (mTOR) is a crucial signaling node that integrates environmental cues to regulate cell survival, proliferation and metabolism, and is often deregulated in human cancer. mTOR kinase acts in two functionally distinct complexes, mTOR complex 1 (mTORC1) and 2 (mTORC2), whose activities and substrate specificities are regulated by complex co-factors. Deregulation of this centralized signaling pathway has been associated with a variety of human diseases including diabetes, neurodegeneration and cancer. Although mTORC1 signaling has been extensively studied in cancer, recent discoveries indicate a subset of human cancers harboring amplifications in mTORC2-specific genes as the only actionable genomic alterations, suggesting a distinct role for mTORC2 in cancer as well. This review will summarize recent advances in dissecting the relative contributions of mTORC1 versus mTORC2 in cancer, their role in tumor-associated blood vessels and tumor immunity, and provide an update on mTOR inhibitors.
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Cites
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Cited by
mTOR signalling and cellular metabolism are mutual determinants in cancer
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mTOR as a central hub of nutrient signalling and cell growth
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The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling
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mTOR: Role in cancer, metastasis and drug resistance
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Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma
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Metadata
- Authors
- Kim, L. C., Cook, R. S., & Chen, J.
- Venue
- Oncogene
- Published
- 2016-10-17
- Volume
- 36
- Issue
- 16
- Pages
- 2191-2201
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2535462468
- Cited by
- 444
- References
- 147
- FWCI
- 17.15
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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