Scientific discourse in the era of open science: a response to Hall et al. regarding the Carbohydrate-Insulin Model
Open accessAbstract
In November 2018, we presented the results of a large macronutrient feeding study at The Obesity Society’s Blackburn Symposium [ 1 ] and simultaneously in BMJ, with peer review available online [ 2 ]. In that study, total energy expenditure (TEE) measured by doubly-labeled water (DLW) at post-weight-loss and at 10 and 20 weeks of weight-loss maintenance was 200–280 kcal/day greater on a low- versus high-carbohydrate diet, consistent with the Carbohydrate-Insulin Model of obesity [ 3 ]. To facilitate scientific discourse, we made the full database immediately available on Open Science Framework.
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Data from a large 5-month study demonstrating increased energy expenditure when consuming a low-carbohydrate diet during weight-loss maintenance appear robust.
“data from a large 5-mo study demonstrating increased energy expenditure when consuming a low-carbohydrate diet during weight-loss maintenance appear robust (106, 153, 154).”
From The carbohydrate-insulin model: A physiological perspective on the obesity pandemic (2021) · cites this paper as [154]
There is dispute about the accuracy of measuring energy expenditure with the doubly labeled water method for individuals on low-carbohydrate diets.
“Additionally, there is dispute about the accuracy of measuring EE with the DLW method for individuals on low-carbohydrate diets [64, 65].”
From Benefits of low carbohydrate diets: a settled question or still controversial? (2021) · cites this paper as [64]
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References 16 · Cited by 18
Research works printed but not linked: 4
- [1]The Obesity Society, News Release, 14 November 2018: George L. Blackburn Symposium to feature weight loss studies https://www.globenewswire.com/news-release/2018/11/14/1651612/0/en/George-L-Blackburn-Symposium-to-Feature-Weight-Loss-Studies.html Accessed 9 July 2019
- [4]Hall KD, Guo J. No significant effect of dietary carbohydrate versus fat on the reduction in total energy expenditure during maintenance of lost weight. BMJ Rapid responses, 28 Nov 2018 https://www.bmj.com/content/363/bmj.k4583/rr-16
- [6]Ludwig DS, Ebbeling CB, Feldman HA. Choice of baseline for primary endpoint. BMJ Rapid responses, 20 Nov 2018 https://www.bmj.com/content/363/bmj.k4583/rr-11
- [7]Ludwig DS, Ebbeling CB. Author response to Hall and Guo regarding data reanalysis and other criticisms. BMJ Rapid responses, 28 Nov 2018 https://www.bmj.com/content/363/bmj.k4583/rr-17
- Authors
- Ludwig, D. S., Lakin, P. R., Wong, W. W., & Ebbeling, C. B.
- Affiliations
- Boston Children's Hospital (US)
- Agricultural Research Service (US)
- Corresponding author
- Ludwig, David S.
- Venue
- International Journal of Obesity
- Published
- 2019-10-04
- Volume
- 43
- Issue
- 12
- Pages
- 2355-2360
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- PMC
- PMC6892734
- OpenAlex
- W2978382829
- Cited by
- 18
- References
- 16
- Citations by year
- 2026: 1 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 6 · 2019: 2
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- International Journal of Obesity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Laura and John Arnold Foundation
- National Institute of Diabetes and Digestive and Kidney Diseases (K24DK082730)
- Topics
- Social Sciences › Decision Sciences › Information Systems and Management › Academic Publishing and Open Access
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Physical Sciences › Computer Science › Information Systems › Research Data Management Practices
- Keywords
- total energy expenditure, low-carbohydrate diet, high-carbohydrate diet, weight loss maintenance, open science, scientific discourse, data sharing, peer review
- MeSH terms
- Energy Intake, Carbohydrates, Humans, Insulin, Obesity, Science
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