Central IGF1 improves glucose tolerance and insulin sensitivity in mice
Open accessAbstract
Insulin-like growth factor 1 (IGF1) is a key factor for tissue growth and fuel metabolism. The potential function of central IGF1 remains unclear. We previously observed that IGF1 expression is increased in the hypothalamus of obese mice lacking STAT5 in the central nervous system (CNS). In this study, we explored the potential metabolic function of central IGF1 by intracerebroventricular (ICV) injection of IGF1, over-expression of central IGF1 by administering an adeno-associated virus (AAV), and ICV injection of an anti-IGF1 antibody. Mice that over-expressed central IGF1 displayed increased appetite, improved glucose tolerance and insulin sensitivity, decreased Pomc levels in the hypothalamus, and increased UCP1 expression in brown fat tissue. This is the first study demonstrating that central IGF1 regulates several important metabolic functions.
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Administration of IGF1 in humans results in decreased blood glucose levels and improved insulin sensitivity in those with and without type 2 diabetes.
“Administration of IGF1 in humans results in decreased blood glucose levels and improved insulin sensitivity in those with and without type 2 diabetes [[234], [235], [236]].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [236]
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References 44 · Cited by 54
- Authors
- Hong, H., Cui, Z.-Z., Zhu, L., Fu, S.-P., Rossi, M., Cui, Y.-H., & Zhu, B.-M.
- Affiliations
- Nanjing University of Chinese Medicine (CN)
- Sichuan University (CN)
- National Institutes of Health (US)
- Corresponding author
- Zhu, Bing-Mei
- Venue
- Nutrition & Diabetes
- Published
- 2017-12-19
- Volume
- 7
- Issue
- 12
- Pages
- 2-2
- ISSN
- 2044-4052 (ISSN-L)
- PMC
- PMC5865549
- OpenAlex
- W2775763986
- Cited by
- 54
- References
- 44
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 9 · 2023: 6 · 2022: 8 · 2021: 14 · 2020: 4 · 2019: 2 · 2018: 1
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Update notices
- correction (2021-02-19)
- Open access
- gold
- doi.org
- Locations
- Nutrition and Diabetes (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- University of Pennsylvania
- National Natural Science Foundation of China (81273838, 81574063)
- Chengdu University
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- insulin-like growth factor I, hypothalamus, glucose tolerance, insulin sensitivity, appetite, proopiomelanocortin, brown adipose tissue, UCP1, obesity, STAT5, intracerebroventricular administration
- MeSH terms
- Uncoupling Protein 1, Animals, Adipose Tissue, Brown, Hypothalamus, Insulin Resistance, Insulin-Like Growth Factor I, Liver, Male, Pro-Opiomelanocortin, Signal Transduction, Glucose Intolerance, Mice
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