An Evolving story of the Metastatic Voyage of Ovarian Cancer Cells: Cellular and Molecular Orchestration of the Adipose-Rich Metastatic Microenvironment
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Metastasis is a complex multistep process that involves critical interactions between cancer cells and a variety of stromal components in the tumor microenvironment, which profoundly influence the different aspects of the metastatic cascade and organ tropism of disseminating cancer cells. Ovarian cancer is the most lethal gynecological malignancy and is characterized by peritoneal disseminated metastasis. Evidence has demonstrated that ovarian cancer possesses specific metastatic tropism for the adipose-rich omentum, which has a pivotal role in the creation of the metastatic tumor microenvironment in the intraperitoneal cavity. Considering the distinct biology of ovarian cancer metastasis, the elucidation of the cellular and molecular mechanisms underlying the reciprocal interplay between ovarian cancer cells and surrounding stromal cell types in the adipose-rich metastatic microenvironment will provide further insights into the development of novel therapeutic approaches for patients with advanced ovarian cancer. Herein, we review the biological mechanisms that regulate the highly orchestrated crosstalk between ovarian cancer cells and various cancer-associated stromal cells in the metastatic tumor microenvironment with regard to the omentum by illustrating how different stromal cells concertedly contribute to the development of ovarian cancer metastasis and metastatic tropism for the omentum.
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Given the location of ovaries, there are no anatomical barriers preventing metastasis to organs in the pelvic cavity including the uterus, bladder, rectum, and small intestine, as well as beyond the peritoneal cavity to organs such as the liver and lung.
“Given the location of ovaries, there are no anatomical barriers preventing metastasis to organs in the pelvic cavity including the uterus, bladder, rectum, and small intestine, as well as beyond the peritoneal cavity to organs such as the liver and lung (Motohara et al., 2019).”
From Three-dimensional modelling of ovarian cancer: from cell lines to organoids for discovery and personalized medicine (2022) · cites this paper as Motohara et al., 2019
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References 116 · Cited by 218
- Authors
- Motohara, T., Masuda, K., Morotti, M., Zheng, Y., El-Sahhar, S., Chong, K. Y., Wietek, N., Alsaadi, A., Carrami, E. M., Hu, Z., Artibani, M., Gonzalez, L. S., Katabuchi, H., Saya, H., & Ahmed, A. A.
- Affiliations
- John Radcliffe Hospital (GB)
- Kumamoto University (JP)
- Keio University (JP)
- Corresponding author
- Ahmed, Ahmed Ashour
- ORCID
- Venue
- Oncogene
- Published
- 2018-12-19
- Volume
- 38
- Issue
- 16
- Pages
- 2885-2898
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- PMC
- PMC6755962
- OpenAlex
- W2904986846
- Cited by
- 218
- References
- 116
- Citations by year
- 2026: 15 · 2025: 25 · 2024: 32 · 2023: 32 · 2022: 47 · 2021: 37 · 2020: 22 · 2019: 8
- FWCI
- 2.53
- Type
- journal article
- Language
- en
- Update notices
- correction (2022-06-06)
- Open access
- hybrid
- doi.org
- Locations
- Oncogene (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Cancer Research UK (S_3768)
- National Institute for Health and Care Research
- Ovarian Cancer Action
- Wellbeing of Women
- National Institutes of Health
- Japan Society for the Promotion of Science
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Surgery › Intraperitoneal and Appendiceal Malignancies
- Keywords
- ovarian cancer, metastasis, omentum, metastatic tropism, peritoneal carcinomatosis, intraperitoneal metastasis, organ tropism
- MeSH terms
- Adipose Tissue, Female, Humans, Omentum, Ovarian Neoplasms, Tropism, Tumor Microenvironment
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