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Disulfiram’s anti-cancer activity reflects targeting NPL4, not inhibition of aldehyde dehydrogenase
Abstract
Aldehyde dehydrogenase (ALDH) is a proposed biomarker and possible target to eradicate cancer stem cells. ALDH inhibition as a treatment approach is supported by anti-cancer effects of the alcohol-abuse drug disulfiram (DSF, Antabuse). Given that metabolic products of DSF, rather than DSF itself inhibit ALDH in vivo, and that DSF's anti-cancer activity is potentiated by copper led us to investigate the relevance of ALDH as the suggested molecular cancer-relevant target of DSF. Here we show that DSF does not directly inhibit ALDH activity in diverse human cell types, while DSF's in vivo metabolite, S-methyl-N,N-diethylthiocarbamate-sulfoxide inhibits ALDH activity yet does not impair cancer cell viability. Our data indicate that the anti-cancer activity of DSF does not involve ALDH inhibition, and rather reflects the impact of DSF's copper-containing metabolite (CuET), that forms spontaneously in vivo and in cell culture media, and kills cells through aggregation of NPL4, a subunit of the p97/VCP segregase. We also show that the CuET-mediated, rather than any ALDH-inhibitory activity of DSF underlies the preferential cytotoxicity of DSF towards BRCA1- and BRCA2-deficient cells. These findings provide evidence clarifying the confusing literature about the anti-cancer mechanism of DSF, a drug currently tested in clinical trials for repositioning in oncology.
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“DIS anticancer effects instead arise from its copper-containing metabolite, which forms spontaneously in vitro and in vivo, that induces nuclear protein localization 4 (NPL4) aggregation, disrupting the p97/valosin-containing protein (VCP) segregase.81”
From Off-label and repurposed use of disulfiram beyond alcohol dependence: A systematic review of clinical and preclinical evidence (2026) · cites this paper as [81]
Citations
Cites
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
Farmer, H., McCabe, N., Lord, C. J., Tutt, A. N. J., Johnson, D. A., Richardson, T. B., Santarosa, M., Dillon, K. J., Hickson, I., Knights, C., et al. (2005) · Nature · doi:10.1038/nature03445 · Cited by 6,683
Ginestier, C., Hur, M. H., Charafe‐Jauffret, E., Monville, F., Dutcher, J. A., Brown, M., Jacquemier, J. D., Viens, P., Kleer, C. G., Liu, S., et al. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.08.014 · Cited by 4,093
Batlle, E., & Clevers, H. (2017) · Nature Medicine · doi:10.1038/nm.4409 · Cited by 2,769
Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4
Skrott, Z., Mistrik, M., Andersen, K. K., Friis, S., Majera, D., Gursky, J., Ozdian, T., Bartkova, J., Turi, Z., Moudry, P., et al. (2017) · Nature · doi:10.1038/nature25016 · Cited by 807
Self-citationNon-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily
Marchitti, S. A., Brocker, C. N., Stagos, D., & Vasiliou, V. (2008) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.4.6.697 · Cited by 806
Charafe-Jauffret, E., Ginestier, C., Iovino, F., Tarpin, C., Diebel, M., Esterni, B., Houvenaeghel, G., Extra, J.-M., Bertucci, F., Jacquemier, J., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1630 · Cited by 732
Chen, D., Cui, Q. C., Yang, H., & Dou, Q. P. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2126 · Cited by 683
Koppaka, V., Thompson, D. C., Chen, Y., Ellermann, M., Nicolaou, K. C., Juvonen, R. O., Petersen, D. R., Deitrich, R. A., Hurley, T. D., & Vasiliou, V. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.005538 · Cited by 561
Yip, N. C., Fombon, I. S., Liu, P., Brown, S., Kannappan, V., Armesilla, A. L., Xu, B., Cassidy, J., Darling, J. L., & Wang, W. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.126 · Cited by 426
van den Hoogen, C., van der Horst, G., Cheung, H., Buijs, J. T., Down, J. M., Guzmán‐Ramírez, N., Hamdy, F. C., Eaton, C. L., Thalmann, G. N., Cecchini, M. G., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3806 · Cited by 403
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Jin, P., Jiang, J., Zhou, L., Huang, Z., Nice, E. C., Huang, C., & Fu, L. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01313-4 · Cited by 299
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Zhou, J., Yu, Q., Song, J., Li, S., Li, X., Kang, B., Chen, H., & Xu, J. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202213922 · Cited by 242
The molecular mechanism and therapeutic landscape of copper and cuproptosis in cancer
Guo, Z., Chen, D., Yao, L., Sun, Y., Li, D., Le, J., Dian, Y., Zeng, F., Chen, X., & Deng, G. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02192-0 · Cited by 221
Disulfiram: a novel repurposed drug for cancer therapy
Chen, L., Li, X., Ren, Y., & Zhang, X. (2021) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-020-04216-8 · Cited by 159
Zhang, H., & Fu, L. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.02.008 · Cited by 155
Lu, Y., Pan, Q., Gao, W., Pu, Y., Luo, K., He, B., & Gu, Z. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2021.121335 · Cited by 149
Kannappan, V., Ali, M., Small, B., Rajendran, G., Elzhenni, S., Taj, H., Wang, W., & Dou, Q. P. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.741316 · Cited by 134
Zhang, P., Zhou, C., Ren, X., Jing, Q., Gao, Y., Yang, C., Shen, Y., Zhou, Y., Hu, W., Jin, F., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.103007 · Cited by 126
Protein lipoylation: mitochondria, cuproptosis, and beyond
Lin, C.-H., Chin, Y., Zhou, M., Sobol, R. W., Hung, M., & Tan, M. (2024) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2024.04.002 · Cited by 119
Pan, M., Zheng, Q., Yu, Y., Ai, H., Xie, Y., Zeng, X., Wang, C., Liu, L., & Zhao, M. (2021) · Nature Communications · doi:10.1038/s41467-020-20359-x · Cited by 108
Cuproptosis: mechanisms and nanotherapeutic strategies in cancer and beyond
Mao, L., Lu, J., Wen, X., Song, Z., Sun, C., Zhao, Y., Huang, F., Chen, S., Jiang, D., Che, W., et al. (2025) · Chemical Society Reviews · doi:10.1039/d5cs00083a · Cited by 104
Cuproptosis: unveiling a new frontier in cancer biology and therapeutics
Feng, Y., Yang, Z., Wang, J., & Hai, Z. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01625-7 · Cited by 91
Gao, X., Huang, H., Pan, C., Mei, Z., Yin, S., Zhou, L., & Zheng, S. (2022) · Cancers · doi:10.3390/cancers14194715 · Cited by 78
Huang, X. Y., Hou, Y., Weng, X., Pang, W., Hou, L., Liang, Y., Wang, Y., Du, L., Wu, T., Yao, M., et al. (2021) · Oncogenesis · doi:10.1038/s41389-020-00295-7 · Cited by 71
Cuproptosis in cancer: biological implications and therapeutic opportunities
Li, L., Zhou, H., & Zhang, C. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00608-3 · Cited by 75
Wang, N., Wang, L., Li, Y., Fu, S.-Y., Xue, X., Jia, L.-N., Yuan, X., Wang, Y., Tang, X., Yang, J., et al. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.11.004 · Cited by 65
Disulfiram: A novel repurposed drug for cancer therapy
Min De, Z. E. N. G., Wu, B., Wei, W., Jiang, Z., Li, P., Quan, Y., & Hu, X. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002909 · Cited by 66
Liu, Y., Guan, X., Wang, M., Wang, N., Chen, Y., Li, B., Xu, Z., Fu, F., Du, C., & Zheng, Z. (2022) · Bioengineered · doi:10.1080/21655979.2022.2038434 · Cited by 56
Disulfiram as a potent metallo-β-lactamase inhibitor with dual functional mechanisms
Chen, C., Yang, K., Wu, L., Li, J., & Sun, L.-Y. (2020) · Chemical Communications · doi:10.1039/c9cc09074f · Cited by 49
Nie, D., Chen, C., Li, Y., & Zeng, C. (2022) · Blood Science · doi:10.1097/bs9.0000000000000117 · Cited by 48
Disulfiram Overcomes Cisplatin Resistance in Human Embryonal Carcinoma Cells
Schmidtova, S., Kaľavská, K., Gercakova, K., Čierna, Z., Miklikova, S., Smolková, B., Buociková, V., Miskovska, V., Durinikova, E., Buríková, M., et al. (2019) · Cancers · doi:10.3390/cancers11091224 · Cited by 45
Wang, Q., Zhu, T., Miao, N., Qu, Y., Wang, Z., Chao, Y., Wang, J., Wu, W., Xu, X., Xu, C., et al. (2022) · The EMBO Journal · doi:10.15252/embj.2022110636 · Cited by 45
Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities
Shan, D., Jinling, S., Ren, Y., Zhang, Y., Ba, Y., Luo, P., Cheng, Q., Xu, H., Weng, S., Zuo, A., et al. (2025) · 癌症:英文版 · doi:10.1002/cac2.70005 · Cited by 53
Majera, D., Skrott, Z., Chroma, K., Merchut-Maya, J. M., Mistrik, M., & Bartek, J. (2020) · Cells · doi:10.3390/cells9020469 · Cited by 43
Self-citationCo-delivery Systems of Multiple Drugs Using Nanotechnology for Future Cancer Therapy
Fumoto, S., & Nishida, K. (2020) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c20-00008 · Cited by 43
Disulfiram-loaded copper sulfide nanoparticles for potential anti-glioma therapy
Lan, Q.-H., Du, C.-C., Yu, R.-J., Zhai, J., Shi, Y., Kou, L., Xiao, J., Lu, C., Zhao, Y., & Yao, Q. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120978 · Cited by 40
Copper-Based Nanomedicines for Cuproptosis-Mediated Effective Cancer Treatment
Noh, D., Lee, H., Lee, S., Sun, I., & Yoon, H. Y. (2024) · Biomaterials Research · doi:10.34133/bmr.0094 · Cited by 41
Enzalutamide Sensitizes Castration‐Resistant Prostate Cancer to Copper‐Mediated Cell Death
Gao, X., Zhao, H., Liu, J., Wang, M., Dai, Z., Hao, W., Wang, Y., Wang, X., Zhang, M., Liu, P., et al. (2024) · Advanced Science · doi:10.1002/advs.202401396 · Cited by 39
Zhuo, X., Liu, Z., Aishajiang, R., Wang, T., & Yu, D. N. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15092293 · Cited by 38
Du, C., Guan, X., Liu, Y., Xu, Z., Du, X., Li, B., Wang, M., & Zheng, Z. (2022) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-022-04398-3 · Cited by 36
Buffet-style Cu(II) for enhance disulfiram-based cancer therapy
Zhao, L., Wang, X., Lou, H., Jiang, M., Wu, X., Qin, J., Zhang, J., Guan, X., Li, W., Zhang, W., et al. (2022) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2022.06.009 · Cited by 34
Chen, C., Nie, D., Huang, Y., Yu, X., Chen, Z., Zhong, M., Liu, X., Wang, X., Sui, S., Liu, Z., et al. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.5ma1121-644r · Cited by 34
Rieber, M. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200628022113 · Cited by 33
Zhang, Q., Chen, Z., Tang, Q., Wang, Z., Lu, J., You, Y., & Wang, H. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05163-3 · Cited by 32
Kang, X., Wang, J., Huang, C.-H., Wibowo, F. S., Amin, R., Chen, P., & Li, F. (2022) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2022.102620 · Cited by 32
Li, X., Du, K., Sun, J., & Feng, F. (2019) · ACS Applied Bio Materials · doi:10.1021/acsabm.9b01014 · Cited by 30
Yoshino, H., Yamada, Y., Enokida, H., Osako, Y., Tsuruda, M., Kuroshima, K., Sakaguchi, T., Sugita, S., Tatarano, S., & Nakagawa, M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0236119 · Cited by 30
Zhong, J., Zheng, X., Wen, Y., Wang, S., Zhan, G., & Chen, A. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.145795 · Cited by 28
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Caminear, M. W., Harrington, B. S., Kamdar, R. D., Kruhlak, M. J., & Annunziata, C. M. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.762820 · Cited by 28
Kanellis, D. C., Zisi, A., Skrott, Z., Lemmens, B., Espinoza, J. A., Kosar, M., Björkman, A., Li, X., Arampatzis, S., Bartkova, J., et al. (2023) · Cell Death & Differentiation · doi:10.1038/s41418-023-01167-4 · Cited by 27
Yang, W., Xiao, C., Zheng, J., Song, J., & Li, X. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107988 · Cited by 27
Lu, X., Lin, B., Xu, N., Huang, H., Wang, Y., & Lin, J.-M. (2020) · Talanta · doi:10.1016/j.talanta.2020.120732 · Cited by 23
Cao, X., Feng, N., Huang, Q., & Liu, Y. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.3c01300 · Cited by 23
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Zhang, S., Zong, Y., Chen, L., Li, Q., Li, Z., & Meng, R. (2023) · Discover Oncology · doi:10.1007/s12672-023-00729-9 · Cited by 23
Ni, X., Ye, C., Xi, Y., Zhang, Y., Hou, Y., Zheng, Q., Chen, Z., Wang, L., Weng, X., Yang, C., et al. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176110 · Cited by 23
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Gruber, F. S., Johnston, Z. C., Barratt, C. L. R., & Andrews, P. D. (2020) · eLife · doi:10.7554/elife.51739 · Cited by 20
Xu, L., Chen, Q., Qian, Y., Wang, J., Wang, C., Fan, R., Shen, J., & Shen, Q. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.161733 · Cited by 22
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Wang, Y.-E., Yang, H. S., Zhao, S., Tian, L., Wu, W., Chen, Y., Wu, X., Zhang, T., Linghu, K., Liu, S., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.146920 · Cited by 19
Read, E., Milford, J., Zhu, J., Wu, L., Bilodeau, M., & Yang, G. (2021) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2021.115642 · Cited by 18
Zhang, J., Lu, M., Xu, H., Ren, F., & Zhu, L. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02756-y · Cited by 17
Serra, R., Zhao, T., Huq, S., Gorelick, N. L., Casaos, J., Cecia, A. F., Mangraviti, A., Eberhart, C. G., Bai, R.-Y., Olivi, A., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0251957 · Cited by 16
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Ren, X., Luo, X., Wang, F., Wan, L., Wang, X., Xiong, J., Ye, M., Rui, S., Liu, Z., Wang, S., et al. (2024) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2024.100948 · Cited by 16
Chromá, K., Škrott, Z., Gurský, J., Bačovský, J., Moudrý, P., Buchtová, T., Mistrík, M., & Bártek, J. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04651-w · Cited by 17
Wang, J., Tian, Q., Liu, Y., Cai, C., Fu, S., Li, J., Guan, Y., Liao, X., Su, D., Sun, T., et al. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02414-7 · Cited by 18
Meraz-Torres, F., Niessner, H., Plöger, S., Riel, S., Schörg, B. F., Casadei, N., Kneilling, M., Schaller, M., Flatz, L., Maček, B., et al. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02941-5 · Cited by 15
Cuproptosis in cancer therapy: mechanisms, therapeutic application and future prospects
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Mandell, J. B., Douglas, N., Ukani, V., Beumer, J. H., Guo, J., Payne, J., Newman, R., Mancinelli, L., Intini, G., Anderson, C. J., et al. (2022) · Sarcoma · doi:10.1155/2022/7157507 · Cited by 15
Effect of Sepatronium Bromide (YM-155) on DNA Double-Strand Breaks Repair in Cancer Cells
Majera, D., & Mistrík, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249431 · Cited by 13
Self-citationKryczka, J., Kryczka, J. M., Janczewski, Ł., Gajda, A., Fraczyk, A., Boncela, J., Kolesińska, B., & Brzeziańska‐Lasota, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158644 · Cited by 12
Ling, J., Cai, Y., Feng, H., Liu, Z., & Ouyang, X. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16040512 · Cited by 12
Xu, N., Yang, Y., Chen, L., & Lin, J. (2020) · ACS Omega · doi:10.1021/acsomega.0c00293 · Cited by 12
Buchtova, T., Skrott, Z., Chroma, K., Rehulka, J., Dzubak, P., Hajduch, M., Lukac, D., Arampatzis, S., Bartek, J., & Mistrik, M. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13114 · Cited by 11
Xi, J., Lei, S.-Y., Chen, J., Liu, J., Shan, C., Sun, X., Zheng, Q., & Shi, X. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02558-x · Cited by 12
A nanosystem of copper(II)-disulfiram for cancer treatment with high efficacy and few side effects
Zhao, L., Wang, X., Jiang, M., Wu, X., Zhang, M., Guan, X., Ma, J., & Zhang, W. (2021) · Frontiers of Materials Science · doi:10.1007/s11706-021-0576-2 · Cited by 11
Chang, M. R., Rusanov, D. A., Arakelyan, J., Alshehri, M. M., Asaturova, A. V., Kireeva, G. S., Babak, M. V., & Ang, W. H. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214923 · Cited by 11
Popović, K. J., Popović, D. J., Miljković, D., Popović, J. K., Lalošević, D., Poša, M., & Čapo, I. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112168 · Cited by 10
Identification of novel dithiocarbamate-copper complexes targeting p97/NPL4 pathway in cancer cells
Löffelmann, M., Škrott, Z., Majera, D., Štarha, P., Kryštof, V., & Mistrík, M. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115790 · Cited by 8
Self-citationCarvalho, D. M., Temelso, S., Mackay, A. G., Pemberton, H. N., Rogers, R. F., Kessler, K., Izquierdo, E., Bjerke, L. M., Salom, J. F., Clarke, M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.29.424674 · Cited by 10
Nuclear bodies protect phase separated proteins from degradation in stressed proteomePreprint
Jung, K. H., Sun, J., Hsiung, C., Lian, X. L., Liu, Y., & Zhang, X. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.19.537522 · Cited by 8
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Ayatollahi, H., Rahmati, A., Goudarzi, S., Sheikhi, M., Siyadat, P., & Ferns, G. A. (2022) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520622666220610154043 · Cited by 7
Ai, L., Yi, N., Qiu, C., Huang, W., Zhang, K., Hou, Q., Jia, L., Li, H., & Liu, L. (2024) · International Journal of Oncology · doi:10.3892/ijo.2024.5634 · Cited by 9
Hu, X., Hu, T., Cao, S., Jiang, L., Zhou, Y., Fang, Q., & Wang, J. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07927-z · Cited by 6
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Drozdková, D. W., & Trtková, K. S. (2021) · Current Oncology · doi:10.3390/curroncol28030193 · Cited by 6
Fang, X., Wang, X., Hao, M., Zhong, G., Gao, M., Pan, Y., Pan, Y., Yang, H., Yin, X., Shen, J., et al. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177649 · Cited by 5
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Gao, Y., Cai, X., Zou, W., Tang, X., Jiang, L., Hao, J., Zheng, Y., Ye, X., Ying, T., & Li, A. (2024) · RSC Advances · doi:10.1039/d4ra01075b · Cited by 5
Meng, Y. G., Wu, Q., Zhang, M., Lai, M., Chen, W., Yang, J., Li, J., & Cao, J. (2023) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2200405 · Cited by 5
Nuclear bodies protect phase separated proteins from degradation in stressed proteomePreprint
Jung, K. H., Sun, J., Hsiung, C., Lian, X. L., Liu, Y., & Zhang, X. (2023) · doi:10.7554/elife.88237.1 · Cited by 5
He, Q., Jia, B.-X., Luo, Z.-R., Wang, Y.-K., Zhang, B., Liao, T., Guang, X.-Y., Feng, Y.-F., Zhang, Z., & Zhou, B. (2024) · Chemical Science · doi:10.1039/d3sc05300h · Cited by 4
Rodríguez‐Acebes, S., Martín-Rufo, R., Gómez-Moya, A., Churcher, S. B., Fernández-Llorente, A., de la Vega-Barranco, G., Perona, A., Oroz, P., Martín‐Doncel, E., Toledo, L. I., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60077-w · Cited by 5
Munz, N., Arribas, A. J., Pittau, R. B., Simonetta, F., Stüssi, G., & Bertoni, F. (2025) · British Journal of Haematology · doi:10.1111/bjh.70185 · Cited by 4
Repurposing Disulfiram as a Chemo-Therapeutic Sensitizer: Molecular Targets and Mechanisms
Sun, F., Wang, H., Nie, J. J., & Hong, B. (2022) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520621666220415102553 · Cited by 4
Lin, H., Sun, F., Li, T., Zhang, Y., Guo, X., Li, M., Liang, M., Zhou, X., & Fang, Z. (2022) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-022-04481-9 · Cited by 4
Du, R., Sun, F., Li, K., Qi, J., Zhong, W., Wang, W., Sun, Q., Deng, Q., Wang, H., Nie, J. J., et al. (2023) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520623666230516161200 · Cited by 4
NPLOC4 is a potential target and a poor prognostic signature in lung squamous cell carcinoma
Wang, N., Zhu, D., Liu, Y., Wu, J., Wang, M., Jin, S., Fu, F., Li, B., Ji, H., Du, C., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-47782-6 · Cited by 5
Wang, K., Wang, Z., Peng, W., Li, G., Xiao, H., Zhong, Z., He, Y., Yu, Y., Song, Y., Xiang, L., et al. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02899-7 · Cited by 4
Ambivalent Copper: Mechanistically Distinct Immune Effects Driving Innovation in Cancer Nanomedicine
Heroux, D., Sun, X., Nosrati, Z., & Bally, M. B. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18010075 · Cited by 4
Han, X., Peng, Z., Cao, K., & Liang, G. (2026) · APOPTOSIS · doi:10.1007/s10495-026-02352-9 · Cited by 3
Liu, L., Liu, Z., Tian, L., Huang, Z., Zhang, W., & Li, J. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.137469 · Cited by 2
Drug Repurposing for Targeting Cancer Stem-like Cells in Glioblastoma
Sousa‐Coelho, A. L. D., Solaković, B., Bento, A. D., & Fernandes, M. T. (2025) · Cancers · doi:10.3390/cancers17182999 · Cited by 2
Zheng, P., Liu, C., Wu, Y., Xu, R., Chen, Y., Hu, F., Chen, Z., & Zhang, T. (2021) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.202100031 · Cited by 2
Drug Repurposing and DNA Damage in Cancer Treatment: Facts and Misconceptions
Sertedaki, E., & Kotsinas, A. (2020) · Cells · doi:10.3390/cells9051210 · Cited by 2
Metadata
- Authors
- Skrott, Z., Majera, D., Gursky, J., Buchtova, T., Hajduch, M., Mistrik, M., & Bartek, J.
- Venue
- Oncogene
- Published
- 2019-08-07
- Volume
- 38
- Issue
- 40
- Pages
- 6711-6722
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2965238366
- Cited by
- 115
- References
- 43
- Citations by year
- 2026: 7 · 2025: 18 · 2024: 18 · 2023: 17 · 2022: 23 · 2021: 16 · 2020: 13 · 2019: 2
- FWCI
- 10.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Novo Nordisk Fonden (NNF15OC0016584)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- disulfiram, aldehyde dehydrogenase, Npl4, cancer stem cells, BRCA1 deficiency, BRCA2 deficiency, drug repurposing, anticancer mechanism, protein aggregation
- MeSH terms
- A549 Cells, Aldehyde Dehydrogenase, Antineoplastic Agents, Culture Media, Disulfiram, Humans, Nuclear Proteins, K562 Cells, Acetaldehyde Dehydrogenase Inhibitors
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