The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Midkine (MDK) growth factor: a key player in cancer progression and a promising therapeutic target
Open accessAbstract
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development. Midkine is abnormally expressed at high levels in various human malignancies and acts as a mediator for the acquisition of critical hallmarks of cancer, including cell growth, survival, metastasis, migration, and angiogenesis. Several studies have investigated the role of midkine as a cancer biomarker for the detection, prognosis, and management of cancer, as well as for monitoring the response to cancer treatment. Moreover, several efforts are also being made to elucidate its underlying mechanisms in therapeutic resistance and immunomodulation within the tumor microenvironment. We hereby summarize the current knowledge on midkine expression and function in cancer development and progression, and highlight its promising potential as a cancer biomarker and as a future therapeutic target in personalized cancer medicine.
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Cited by
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Analysis of intracellular and intercellular crosstalk from omics data
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Metadata
- Authors
- Filippou, P. S., Karagiannis, G. S., & Constantinidou, A.
- Venue
- Oncogene
- Published
- 2019-12-04
- Volume
- 39
- Issue
- 10
- Pages
- 2040-2054
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2992156287
- Cited by
- 331
- References
- 99
- FWCI
- 14.08
- Type
- journal article
- Language
- en
- Open access
- green
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- Filippou, P. S., Karagiannis, G. S., & Constantinidou, A. (2020). Midkine (MDK) growth factor: a key player in cancer progression and a promising therapeutic target. Oncogene. https://doi.org/10.1038/s41388-019-1124-8
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
