The DOI matches its Crossref record; 241 of the 241 references it cites were found in a registry or an index.
Immunosenescence: molecular mechanisms and diseases
Open accessAbstract
Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms are linked to innate and adaptive immune dysfunction that accompanies aging (known as immunosenescence). During aging, organisms tend to develop a characteristic inflammatory state that expresses high levels of pro-inflammatory markers, termed inflammaging. This chronic inflammation is a typical phenomenon linked to immunosenescence and it is considered the major risk factor for age-related diseases. Thymic involution, naïve/memory cell ratio imbalance, dysregulated metabolism, and epigenetic alterations are striking features of immunosenescence. Disturbed T-cell pools and chronic antigen stimulation mediate premature senescence of immune cells, and senescent immune cells develop a proinflammatory senescence-associated secretory phenotype that exacerbates inflammaging. Although the underlying molecular mechanisms remain to be addressed, it is well documented that senescent T cells and inflammaging might be major driving forces in immunosenescence. Potential counteractive measures will be discussed, including intervention of cellular senescence and metabolic-epigenetic axes to mitigate immunosenescence. In recent years, immunosenescence has attracted increasing attention for its role in tumor development. As a result of the limited participation of elderly patients, the impact of immunosenescence on cancer immunotherapy is unclear. Despite some surprising results from clinical trials and drugs, it is necessary to investigate the role of immunosenescence in cancer and other age-related diseases.
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Cites
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BackgroundInflamm‐aging: An Evolutionary Perspective on Immunosenescence
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Cited by
The Impact of Immune System Aging on Infectious Diseases
Quiros-Roldan, E., Sottini, A., Natali, P. G., & Imberti, L. (2024) · Microorganisms · doi:10.3390/microorganisms12040775 · Cited by 133
“More generally, immunosenescence refers to a series of complex changes leading to altered innate and adaptive immune system functions which, overall, may result in a state of immunodeficiency [15].”
Jang, D., Shin, J., Shim, E., Ohtani, N., & Jeon, O. H. (2024) · Aging Cell · doi:10.1111/acel.14315 · Cited by 84
Targeting aging and age-related diseases with vaccines
Wu, R., Sun, F., Zhang, W., Ren, J., & Liu, G.-H. (2024) · Nature Aging · doi:10.1038/s43587-024-00597-0 · Cited by 66
Theodorakis, N., Feretzakis, G., Tzelves, L., Paxinou, E., Hitas, C., Vamvakou, G., Verykios, V. S., & Nikolaou, M. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14090931 · Cited by 51
Fuentealba, M., Rouch, L., Guyonnet, S., Lemaitre, J.-M., de Souto Barreto, P., Vellas, B., Andrieu, S., & Furman, D. (2025) · Nature Aging · doi:10.1038/s43587-025-00883-5 · Cited by 51
Metadata
- Authors
- Liu, Z., Liang, Q., Ren, Y., Guo, C., Ge, X., Wang, L., Cheng, Q., Luo, P., Zhang, Y., & Han, X.
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2023-05-13
- Volume
- 8
- Issue
- 1
- Pages
- 200-200
- ISSN
- 2059-3635 (ISSN-L)
- OpenAlex
- W4376631082
- Cited by
- 960
- References
- 241
- FWCI
- 138.87
- Type
- journal article
- Language
- en
- Open access
- gold
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