Oral Antibiotics Reduce Intestinal Necrosis in Acute Mesenteric Ischemia: A Prospective Cohort Study
Abstract
OBJECTIVES: To identify treatments likely to prevent progression towards irreversible transmural intestinal necrosis (ITIN) in acute mesenteric ischemia (AMI). METHODS: Prospective observational cohort study from a French intestinal stroke center. Multivariate analysis using a time-dependent Cox regression model. RESULTS: Between 2009 and 2015, 67 patients with AMI were included. ITIN occurred in 34% of patients and mortality was 13%. Oral antibiotics was independently associated with a decreased risk of ITIN (HR: 0.16 (95% CI = 0.03–0.62); p = 0.01). CONCLUSIONS: By decreasing luminal bacterial load and translocation, oral antibiotics in addition to early revascularization might reduce progression of AMI to ITIN.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
One observational study of 67 patients showed that administration of oral gentamicin and metronidazole was independently associated with a decreased risk of irreversible intestinal necrosis in AMI.
“One observational study of 67 patients showed that administration of oral gentamicin and metronidazole was independently associated with a decreased risk of irreversible intestinal necrosis in AMI. 178”
The citation lists haven’t been fetched yet
References 15 · Cited by 45
- Authors
- Nuzzo, A., Maggiori, L., Paugam-Burtz, C., Cazals-Hatem, D., Ronot, M., Huguet, A., Becq, A., Castier, Y., Weiss, E., Plessier, A., Tran-Dinh, A., Joly, F., Panis, Y., Bouhnik, Y., Gault, N., Corcos, O., & on behalf of the SURVI group
- Affiliations
- Hôpital Beaujon (FR)
- APHP, Department of Colorectal Surgery, Beaujon Hospital, 92110, Clichy, France;
- APHP, Department of Anesthesia and Intensive Care, Beaujon Hospital, 92110, Clichy, France;
- Sorbonne Paris Cité (FR)
- Hôpital Bichat-Claude-Bernard (FR)
- APHP, Department of Surgical France;
- Inserm (FR)
- Corresponding author
- Nuzzo, Alexandre
- ORCID
- Venue
- American Journal of Gastroenterology
- Published
- 2018-12-11
- Volume
- 114
- Issue
- 2
- Pages
- 348-351
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- OpenAlex
- W2904900924
- Cited by
- 45
- References
- 15
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 7 · 2023: 8 · 2022: 6 · 2021: 6 · 2020: 6 · 2019: 1
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Health Sciences › Medicine › Emergency Medicine › Appendicitis Diagnosis and Management
- Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
- Keywords
- acute mesenteric ischemia, oral antibiotics, intestinal necrosis, bacterial translocation, early revascularization, mortality, intestinal ischemia
- MeSH terms
- Administration, Oral, Adult, Aged, Anti-Bacterial Agents, Anticoagulants, Blood Transfusion, Female, Fluid Therapy, Humans, Intestines, Male, Mesenteric Vascular Occlusion, Middle Aged, Necrosis, Prospective Studies, Vascular Surgical Procedures, Cohort Studies, Proportional Hazards Models, Disease Progression, Proton Pump Inhibitors, Mesenteric Ischemia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
