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Cited by 1,205

The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.

Cytokines in clinical cancer immunotherapy

Open access
Berraondo, Pedro, Sanmamed, Miguel F., Ochoa, María C, Etxeberria, Iñaki, Aznar, Maria A., Pérez-Gracia, José Luis, Rodríguez-Ruiz, María E., Ponz-Sarvise, Mariano, Castañón, Eduardo, Melero, Ignacio·2019·British Journal of Cancer
DOI 10.1038/s41416-018-0328-y
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Abstract

Cytokines are soluble proteins that mediate cell-to-cell communication. Based on the discovery of the potent anti-tumour activities of several pro-inflammatory cytokines in animal models, clinical research led to the approval of recombinant interferon-alpha and interleukin-2 for the treatment of several malignancies, even if efficacy was only modest. These early milestones in immunotherapy have been followed by the recent addition to clinical practice of antibodies that inhibit immune checkpoints, as well as chimeric antigen receptor T cells. A renewed interest in the anti-tumour properties of cytokines has led to an exponential increase in the number of clinical trials that explore the safety and efficacy of cytokine-based drugs, not only as single agents, but also in combination with other immunomodulatory drugs. These second-generation drugs under clinical development include known molecules with novel mechanisms of action, new targets, and fusion proteins that increase half-life and target cytokine activity to the tumour microenvironment or to the desired effector immune cells. In addition, the detrimental activity of immunosuppressive cytokines can be blocked by antagonistic antibodies, small molecules, cytokine traps or siRNAs. In this review, we provide an overview of the novel trends in the cytokine immunotherapy field that are yielding therapeutic agents for clinical trials.

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Metadata

Authors
Berraondo, P., Sanmamed, M. F., Ochoa, M. C., Etxeberria, I., Aznar, M. A., Pérez-Gracia, J. L., Rodríguez-Ruiz, M. E., Ponz-Sarvise, M., Castañón, E., & Melero, I.
Venue
British Journal of Cancer
Publisher
Springer Science and Business Media LLC
Published
2018-11-09
Volume
120
Issue
1
Pages
6-15
ISSN
  • 0007-0920 (ISSN-L)
  • 1532-1827
DOI
10.1038/s41416-018-0328-y
OpenAlex
W2900046418
Cited by
1,205
References
108
FWCI
25.53
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Cytokines in clinical cancer immunotherapy. https://app.cochat.ai/papers/10.1038/s41416-018-0328-y
The paper
Berraondo, P., Sanmamed, M. F., Ochoa, M. C., Etxeberria, I., Aznar, M. A., Pérez-Gracia, J. L., Rodríguez-Ruiz, M. E., Ponz-Sarvise, M., Castañón, E., & Melero, I. (2019). Cytokines in clinical cancer immunotherapy. British Journal of Cancer. https://doi.org/10.1038/s41416-018-0328-y

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.