The role of miR-106p-5p in cervical cancer: from expression to molecular mechanism
Open accessAbstract
This study aims to investigate the role of miR-106b-5p in cervical cancer by performing a comprehensive analysis on its expression and identifying its putative molecular targets and pathways based on The Cancer Genome Atlas (TCGA) dataset, Gene Expression Omnibus (GEO) dataset, and literature review. Significant upregulation of miR-106b-5p in cervical cancer is confirmed by meta-analysis with the data from TCGA, GEO, and literature. Moreover, the expression of miR-106b-5p is significantly correlated with the number of metastatic lymph nodes. Our bioinformatics analyses show that miR-106b could promote cervical cancer progression by modulating the expression of GSK3B, VEGFA, and PTK2 genes. Importantly, these three genes play a crucial role in PI3K-Akt signaling, focal adhesion, and cancer. Both the expression of miR-106b-5p and key genes are upregulated in cervical cancer. Several explanations could be implemented for this upregulation. However, the specific mechanism needs to be investigated further.
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miR-106b-5p is an oncogenic miRNA that appears to be upregulated in hepatic cancer, cervical cancer, gliomas, and gastric cancer.
“miR-106b-5p is an oncogenic miRNA that appears to be upregulated in different cancers, such as hepatic cancer,232 cervical cancer,233 gliomas,234 and gastric cancer.235”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [233]
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References 71 · Cited by 23
Research works printed but not linked: 1
- [54]R. Core Team. R: A Language and Environment for Statistical Computing, Vol. 1 (R Foundation for Statistical Computing, 2017).
- Authors
- Yi, Y., Liu, Y., Wu, W., Wu, K., & Zhang, W.
- Affiliations
- Zhongnan Hospital of Wuhan University (CN)
- Corresponding author
- Zhang, Wei
- Venue
- Cell Death Discovery
- Published
- 2018-09-20
- Volume
- 4
- Issue
- 1
- Pages
- 36-36
- ISSN
- 2058-7716 (ISSN-L)
- PMC
- PMC6148547
- OpenAlex
- W2891983668
- Cited by
- 23
- References
- 71
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 3 · 2018: 1
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Update notices
- correction (2019-07-10)
- Open access
- gold
- doi.org
- Locations
- Cell Death Discovery (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Keywords
- miR-106b-5p, cervical cancer, microRNA expression, metastatic lymph nodes, GSK3B, VEGF-A, focal adhesion kinase, PI3K/Akt signaling, focal adhesions, tumor progression, molecular targets
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