The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.
Immune dysregulation in sepsis: experiences, lessons and perspectives
Open accessAbstract
Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host responses to infection. Not only does sepsis pose a serious hazard to human health, but it also imposes a substantial economic burden on the healthcare system. The cornerstones of current treatment for sepsis remain source control, fluid resuscitation, and rapid administration of antibiotics, etc. To date, no drugs have been approved for treating sepsis, and most clinical trials of potential therapies have failed to reduce mortality. The immune response caused by the pathogen is complex, resulting in a dysregulated innate and adaptive immune response that, if not promptly controlled, can lead to excessive inflammation, immunosuppression, and failure to re-establish immune homeostasis. The impaired immune response in patients with sepsis and the potential immunotherapy to modulate the immune response causing excessive inflammation or enhancing immunity suggest the importance of demonstrating individualized therapy. Here, we review the immune dysfunction caused by sepsis, where immune cell production, effector cell function, and survival are directly affected during sepsis. In addition, we discuss potential immunotherapy in septic patients and highlight the need for precise treatment according to clinical and immune stratification.
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Cites
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Annane, D. (2002) · JAMA · doi:10.1001/jama.288.7.862 · Cited by 3,087
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448 · cited 1×
“Neutralizing monoclonal anti-cachectin/TNF α monoclonal antibodies injected only one hour before a bacterial attack in baboons prevented shock, while two hours prevented essential organ dysfunction and mortality [26].”
BackgroundHydrocortisone Therapy for Patients with Septic Shock
Sprung, C. L., Annane, D., Keh, D., Moreno, R., Singer, M., Freivogel, K., Weiss, Y. G., Benbenishty, J., Kalenka, A., Forst, H., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa071366 · Cited by 2,132
Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis
Seymour, C. W., Kennedy, J. N., Wang, S., Chang, C.-C. H., Elliott, C. F., Xu, Z., Berry, S., Clermont, G., Cooper, G., Gomez, H., et al. (2019) · JAMA · doi:10.1001/jama.2019.5791 · Cited by 1,567
Adjunctive glucocorticoid therapy in patients with septic shock.
Venkatesh, B., Finfer, S., Cohen, J., Rajbhandari, D., Arabi, Y., Bellomo, R., Billot, L., Correa, M., Glass, P., Harward, M., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1705835 · Cited by 1,037
Hydrocortisone plus fludrocortisone for adults with septic shock.
Annane, D., Renault, A., Brun-Buisson, C., Megarbane, B., Quenot, J.-P., Siami, S., Cariou, A., Forceville, X., Schwebel, C., Martin, C., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1705716 · Cited by 939
Shakoory, B., Carcillo, J. A., Chatham, W. W., Amdur, R. L., Zhao, H., Dinarello, C. A., Cron, R. Q., & Opal, S. M. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001402 · Cited by 867
Opal, S. M., Fisher, C. J., Dhainaut, J.-F. A., Vincent, J.-L., Brase, R., Lowry, S. F., Sadoff, J. C., Slotman, G. J., Levy, H., Balk, R. A., et al. (1997) · Critical Care Medicine · doi:10.1097/00003246-199707000-00010 · Cited by 865
Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study
Davenport, E. E., Burnham, K. L., Radhakrishnan, J., Humburg, P., Hutton, P., Mills, T. C., Rautanen, A., Gordon, A. C., Garrard, C., Hill, A. V. S., et al. (2016) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(16)00046-1 · Cited by 856
Metadata
- Authors
- Cao, M., Wang, G., & Xie, J.
- Venue
- Cell Death Discovery
- Published
- 2023-12-19
- Volume
- 9
- Issue
- 1
- Pages
- 465-465
- ISSN
- 2058-7716 (ISSN-L)
- OpenAlex
- W4389935431
- Cited by
- 259
- References
- 130
- FWCI
- 43.32
- Type
- journal article
- Language
- en
- Open access
- gold
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- Cao, M., Wang, G., & Xie, J. (2023). Immune dysregulation in sepsis: experiences, lessons and perspectives. Cell Death Discovery. https://doi.org/10.1038/s41420-023-01766-7
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
