The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis
Open accessAbstract
Global warming has profound effects on plant growth and fitness. Plants have evolved sophisticated epigenetic machinery to respond quickly to heat, and exhibit transgenerational memory of the heat-induced release of post-transcriptional gene silencing (PTGS). However, how thermomemory is transmitted to progeny and the physiological relevance are elusive. Here we show that heat-induced HEAT SHOCK TRANSCRIPTION FACTOR A2 (HSFA2) directly activates the H3K27me3 demethylase RELATIVE OF EARLY FLOWERING 6 (REF6), which in turn derepresses HSFA2. REF6 and HSFA2 establish a heritable feedback loop, and activate an E3 ubiquitin ligase, SUPPRESSOR OF GENE SILENCING 3 (SGS3)-INTERACTING PROTEIN 1 (SGIP1). SGIP1-mediated SGS3 degradation leads to inhibited biosynthesis of trans-acting siRNA (tasiRNA). The REF6-HSFA2 loop and reduced tasiRNA converge to release HEAT-INDUCED TAS1 TARGET 5 (HTT5), which drives early flowering but attenuates immunity. Thus, heat induces transmitted phenotypes via a coordinated epigenetic network involving histone demethylases, transcription factors, and tasiRNAs, ensuring reproductive success and transgenerational stress adaptation.
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Self-citationTranscription factor PIF4 controls the thermosensory activation of flowering
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Cited by
Plant Responses to Heat Stress: Physiology, Transcription, Noncoding RNAs, and Epigenetics
Zhao, J., Lu, Z., Wang, L., & Jin, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010117 · Cited by 455
Plant-Microbe Interactions Facing Environmental Challenge
Cheng, Y. T., Zhang, L., & He, S. Y. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.07.009 · Cited by 359
Metadata
- Authors
- Liu, J., Feng, L., Gu, X., Deng, X., Qiu, Q., Li, Q., Zhang, Y., Wang, M., Deng, Y., Wang, E., He, Y., Bäurle, I., Li, J., Cao, X., & He, Z.
- Venue
- Cell Research
- Published
- 2019-02-18
- Volume
- 29
- Issue
- 5
- Pages
- 379-390
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- OpenAlex
- W2914202194
- Cited by
- 266
- References
- 47
- FWCI
- 18.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Liu, J., Feng, L., Gu, X., Deng, X., Qiu, Q., Li, Q., Zhang, Y., Wang, M., Deng, Y., Wang, E., He, Y., Bäurle, I., Li, J., Cao, X., & He, Z. (2019). An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis. Cell Research. https://doi.org/10.1038/s41422-019-0145-8
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