The function and clinical application of extracellular vesicles in innate immune regulation
Open accessAbstract
The innate immune system plays a crucial role in the host defense against viral and microbial infection. Exosomes constitute a subset of extracellular vesicles (EVs) that can be released by almost all cell types. Owing to their capacity to shield the payload from degradation and to evade recognition and subsequent removal by the immune system, exosomes efficiently transport functional components to recipient cells. Accumulating evidence has recently shown that exosomes derived from tumor cells, host cells and even bacteria and parasites mediate the communication between the invader and innate immune cells and thus play an irreplaceable function in the dissemination of pathogens and donor cell-derived molecules, modulating the innate immune responses of the host. In this review, we describe the current understanding of EVs (mainly focusing on exosomes) and summarize and discuss their crucial roles in determining innate immune responses. Additionally, we discuss the potential of using exosomes as biomarkers and cancer vaccines in diagnostic and therapeutic applications.
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Natural or surface-modified exosomes can be used as a treatment for autoimmune diseases.
“Previous studies have proved that natural or surface-modified exosomes can be used as a treatment for autoimmune diseases [76].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [76]
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References 226 · Cited by 294
- Authors
- Zhou, X., Xie, F., Wang, L., Zhang, L., Zhang, S., Fang, M., & Zhou, F.
- Affiliations
- Soochow University (CN)
- Zhejiang Cancer Hospital (CN)
- Shenzhen University (CN)
- Corresponding author
- Zhou, Fangfang
- Venue
- Cellular & Molecular Immunology
- Published
- 2020-03-19
- Volume
- 17
- Issue
- 4
- Pages
- 323-334
- ISSN
- 1672-7681 (ISSN-L)
- 2042-0226
- PMC
- PMC7109106
- OpenAlex
- W3011689356
- Cited by
- 294
- References
- 226
- Citations by year
- 2026: 25 · 2025: 50 · 2024: 54 · 2023: 39 · 2022: 59 · 2021: 52 · 2020: 15
- FWCI
- 3.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cellular and Molecular Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (19KJA550003)
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province (BK20180043, 19KJA550003)
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- National Postdoctoral Program for Innovative Talents (BX201700165)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- extracellular vesicles, exosomes, innate immunity, immune regulation, pathogen dispersal, tumor-derived exosomes, host-pathogen communication, exosomal biomarkers, cancer vaccines, immune evasion
- MeSH terms
- Extracellular Vesicles, Animals, Humans, Immunity, Innate, Immunosuppression Therapy, Models, Biological, Neoplasms, Exosomes
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