HBeAg induces liver sinusoidal endothelial cell activation to promote intrahepatic CD8 T cell immunity and HBV clearance

Xie, Xiaohong; Luo, Jinzhuo; Broering, Ruth; Zhu, Dan; Zhou, Wenqing; Lu, Mengji; Zheng, Xin; Dittmer, Ulf; Yang, Dongliang; Liu, Jia

doi:10.1038/s41423-021-00769-7

HBeAg induces liver sinusoidal endothelial cell activation to promote intrahepatic CD8 T cell immunity and HBV clearance

TO THE EDITOR It is believed that the inherent tolerogenic property of the liver is involved in the chronicity of hepatitis B virus (HBV) infection [1]. However, exposure to HBV in adults usually leads to spontaneous clearance of the virus and the induction of potent and effective anti-HBV T cell…