Labrenzbactin from a coral-associated bacterium Labrenzia sp
Abstract
A new catecholate-containing siderophore, labrenzbactin (1), was isolated from the fermentation broth of a coral-associated bacterium Labrenzia sp. The structure and absolute configuration of 1 was determined by spectroscopic methods and Marfey's analysis. Overall, 1 showed antimicrobial activity against Ralstonia solanacearum SUPP1541 and Micrococcus luteus ATCC9341 with MIC values of 25 and 50 µg ml-1, respectively, and cytotoxicity against P388 murine leukemia cells with an IC 50 of 13 µM.
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Pseudomonas, Acinetobacter and Labrenzia are genera found in marine environments.
“Bacterial communities specifically associated with the egg samples (Fig. 5B) were dominated by Pseudomonas, Acinetobacter and Labrenzia, 3 genera found in marine environments (Fournier & Richet, 2006; Palleroni, 2015; Raj Sharma et al., 2019) and which had already been studied during the development of L. vannamei and P. monodon (Rungrassamee et al., 2013; Wang et al., 2020a; Wang et al., 2020b).”
From Potential lineage transmission within the active microbiota of the eggs and the nauplii of the shrimp <i>Litopenaeus stylirostris</i> : possible influence of the rearing water and more (2021) · cites this paper as Raj Sharma et al., 2019
Labrenzia are known to produce labrenzbactin, a catecholate-containing siderophore which demonstrates antimicrobial activity against Micrococcus luteus.
“Concerning Labrenzia, they are known to produce labrenzbactin, a catecholate-containing siderophore which demonstrates an antimicrobial activity against Micrococcus luteus (Raj Sharma et al., 2019).”
From Potential lineage transmission within the active microbiota of the eggs and the nauplii of the shrimp <i>Litopenaeus stylirostris</i> : possible influence of the rearing water and more (2021) · cites this paper as Raj Sharma et al., 2019
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References 21 · Cited by 47
- Authors
- Raj Sharma, A., Zhou, T., Harunari, E., Oku, N., Trianto, A., & Igarashi, Y.
- Affiliations
- Toyama Prefectural University (JP)
- Diponegoro University (ID)
- Corresponding author
- Igarashi, Yasuhiro
- Venue
- The Journal of Antibiotics
- Published
- 2019-05-22
- Volume
- 72
- Issue
- 8
- Pages
- 634-639
- ISSN
- 0021-8820 (ISSN-L)
- 1881-1469
- OpenAlex
- W2945219644
- Cited by
- 47
- References
- 21
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 7 · 2022: 11 · 2021: 10 · 2020: 10 · 2019: 1
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Antibiotics (publishedVersion)
- PubMed (publishedVersion)
- UNDIP Institutional Repository (UNDIP-IR) (Diponegoro University) (acceptedVersion)
- Funders
- Japan Society for the Promotion of Science (18K05827)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Metabolism and Applications
- Keywords
- siderophores, catecholate siderophores, Labrenzia, coral-associated bacteria, natural product isolation, structure elucidation, absolute configuration, antimicrobial activity, Ralstonia solanacearum, Micrococcus luteus, cytotoxicity, P388 leukemia cells
- MeSH terms
- Animals, Anti-Bacterial Agents, Antibiotics, Antineoplastic, Catechols, Drug Screening Assays, Antitumor, Fermentation, Leukemia P388, Microbial Sensitivity Tests, Oxazoles, Molecular Structure, Micrococcus luteus, Siderophores, Alphaproteobacteria, Anthozoa, Ralstonia, Mice
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