Collateral fattening in body composition autoregulation: its determinants and significance for obesity predisposition
Open accessAbstract
Collateral fattening refers to the process whereby excess fat is deposited as a result of the body's attempt to counter a deficit in lean mass through overeating. Its demonstration and significance to weight regulation and obesity can be traced to work on energy budget strategies in growing mammals and birds, and to men recovering from experimental starvation. The cardinal features of collateral fattening rests upon (i) the existence of a feedback system between lean tissue and appetite control, with lean tissue deficit driving hyperphagia, and (ii) upon the occurrence of a temporal desynchronization in the recovery of body composition, with complete recovery of fat mass preceeding that of lean mass. Under these conditions, persistent hyperphagia driven by the need to complete the recovery of lean tissue will result in the excess fat deposition (hence collateral fattening) and fat overshooting. After reviewing the main lines of evidence for the phenomenon of collateral fattening in body composition autoregulation, this article discusses the causes and determinants of the desynchronization in fat and lean tissue recovery leading to collateral fattening and fat overshooting, and points to their significance in the mechanisms by which dieting, developmental programming and sedentariness predispose to obesity.
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For every increase in body fat, fat-free mass changes in parallel by approximately 25% (the one quarter rule).
“for any increment in body fat, a parallel change in FFM occurs, corresponding approximately to 25%.”
From Critical appraisal of definitions and diagnostic criteria for sarcopenic obesity based on a systematic review (2020) · cites this paper as [112]
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References 44 · Cited by 37
- Authors
- Dulloo, A. G., Miles-Chan, J. L., & Schutz, Y.
- Affiliations
- University of Fribourg (CH)
- Corresponding author
- Dulloo, Abdul G.
- Venue
- European Journal of Clinical Nutrition
- Published
- 2018-03-20
- Volume
- 72
- Issue
- 5
- Pages
- 657-664
- ISSN
- 0954-3007 (ISSN-L)
- 1476-5640
- PMC
- PMC5945583
- OpenAlex
- W2792996519
- Cited by
- 37
- References
- 44
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 5
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- European Journal of Clinical Nutrition (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RERO DOC (Universität Bern) (submittedVersion)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (176116, 320030)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- obesity predisposition, hyperphagia, appetite regulation, starvation recovery, dieting, developmental programming, sedentary behavior
- MeSH terms
- Adipose Tissue, Aging, Appetite, Appetite Regulation, Body Composition, Body Weight, Diet, Disease Susceptibility, Humans, Hunger, Hyperphagia, Obesity, Body Mass Index, Muscle, Skeletal, Adiposity, Sedentary Behavior
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