The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections
Open accessAbstract
Infectious diseases have a profound impact on our health and many studies suggest that host genetics play a major role in the pathogenesis of most of them. We perform 23 genome-wide association studies for common infections and infection-associated procedures, including chickenpox, shingles, cold sores, mononucleosis, mumps, hepatitis B, plantar warts, positive tuberculosis test results, strep throat, scarlet fever, pneumonia, bacterial meningitis, yeast infections, urinary tract infections, tonsillectomy, childhood ear infections, myringotomy, measles, hepatitis A, rheumatic fever, common colds, rubella and chronic sinus infection, in over 200,000 individuals of European ancestry. We detect 59 genome-wide significant ( P < 5 × 10 −8 ) associations in genes with key roles in immunity and embryonic development. We apply fine-mapping analysis to dissect associations in the human leukocyte antigen region, which suggests important roles of specific amino acid polymorphisms in the antigen-binding clefts. Our findings provide an important step toward dissecting the host genetic architecture of response to common infections.
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Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior
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Metadata
- Authors
- Tian, C., Hromatka, B. S., Kiefer, A. K., Eriksson, N., Noble, S. M., Tung, J. Y., & Hinds, D. A.
- Venue
- Nature Communications
- Published
- 2017-09-19
- Volume
- 8
- Issue
- 1
- Pages
- 599-599
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2952977999
- Cited by
- 411
- References
- 100
- FWCI
- 20.95
- Type
- journal article
- Language
- en
- Open access
- gold
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- Tian, C., Hromatka, B. S., Kiefer, A. K., Eriksson, N., Noble, S. M., Tung, J. Y., & Hinds, D. A. (2017). Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections. Nature Communications. https://doi.org/10.1038/s41467-017-00257-5
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