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RETRACTED ARTICLE: Sulfur availability regulates plant growth via glucose-TOR signaling
Open accessAbstract
Growth of eukaryotic cells is regulated by the target of rapamycin (TOR). The strongest activator of TOR in metazoa is amino acid availability. The established transducers of amino acid sensing to TOR in metazoa are absent in plants. Hence, a fundamental question is how amino acid sensing is achieved in photo-autotrophic organisms. Here we demonstrate that the plant Arabidopsis does not sense the sulfur-containing amino acid cysteine itself, but its biosynthetic precursors. We identify the kinase GCN2 as a sensor of the carbon/nitrogen precursor availability, whereas limitation of the sulfur precursor is transduced to TOR by downregulation of glucose metabolism. The downregulated TOR activity caused decreased translation, lowered meristematic activity, and elevated autophagy. Our results uncover a plant-specific adaptation of TOR function. In concert with GCN2, TOR allows photo-autotrophic eukaryotes to coordinate the fluxes of carbon, nitrogen, and sulfur for efficient cysteine biosynthesis under varying external nutrient supply.
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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., & Shaw, R. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.003 · Cited by 3,849
Cited by
Heinemann, B., & Hildebrandt, T. M. (2021) · Journal of Experimental Botany · doi:10.1093/jxb/erab182 · Cited by 283
Metadata
- Authors
- Dong, Y., Silbermann, M., Speiser, A., Forieri, I., Linster, E., Poschet, G., Allboje Samami, A., Wanatabe, M., Sticht, C., Teleman, A. A., Deragon, J.-M., Saito, K., Hell, R., & Wirtz, M.
- Venue
- Nature Communications
- Published
- 2017-10-27
- Volume
- 8
- Issue
- 1
- Pages
- 1174-1174
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2766298100
- Cited by
- 175
- References
- 1
- FWCI
- 20.72
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- gold
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- CoChat. (2026). Citation check: RETRACTED ARTICLE: Sulfur availability regulates plant growth via glucose-TOR signaling. https://app.cochat.ai/papers/10.1038/s41467-017-01224-w
- The paper
- Dong, Y., Silbermann, M., Speiser, A., Forieri, I., Linster, E., Poschet, G., Allboje Samami, A., Wanatabe, M., Sticht, C., Teleman, A. A., Deragon, J.-M., Saito, K., Hell, R., & Wirtz, M. (2017). RETRACTED ARTICLE: Sulfur availability regulates plant growth via glucose-TOR signaling. Nature Communications. https://doi.org/10.1038/s41467-017-01224-w
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
