The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Control of cell morphology and differentiation by substrates with independently tunable elasticity and viscous dissipation
Open accessAbstract
The mechanical properties of extracellular matrices can control the function of cells. Studies of cellular responses to biomimetic soft materials have been largely restricted to hydrogels and elastomers that have stiffness values independent of time and extent of deformation, so the substrate stiffness can be unambiguously related to its effect on cells. Real tissues, however, often have loss moduli that are 10 to 20% of their elastic moduli and behave as viscoelastic solids. The response of cells to a time-dependent viscous loss is largely uncharacterized because appropriate viscoelastic materials are lacking for quantitative studies. Here we report the synthesis of soft viscoelastic solids in which the elastic and viscous moduli can be independently tuned to produce gels with viscoelastic properties that closely resemble those of soft tissues. Systematic alteration of the hydrogel viscosity demonstrates the time dependence of cellular mechanosensing and the influence of viscous dissipation on cell phenotype.
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Cites
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
Hydrogels with tunable stress relaxation regulate stem cell fate and activity
Chaudhuri, O., Gu, L., Klumpers, D., Darnell, M., Bencherif, S. A., Weaver, J. C., Huebsch, N., Lee, H.-P., Lippens, E., Duda, G. N., et al. (2016) · Nature Materials · doi:10.1038/nmat4489 · Cited by 2,443
Cited by
Effects of extracellular matrix viscoelasticity on cellular behaviour
Chaudhuri, O., Cooper-White, J., Janmey, P. A., Mooney, D. J., & Shenoy, V. B. (2020) · Nature · doi:10.1038/s41586-020-2612-2 · Cited by 2,224
Self-citationJanmey, P. A., Fletcher, D. A., & Reinhart-King, C. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00013.2019 · Cited by 422
Self-citationChemical strategies to engineer hydrogels for cell culture
Lou, J., & Mooney, D. J. (2022) · Nature Reviews Chemistry · doi:10.1038/s41570-022-00420-7 · Cited by 386
Machine Learning‐Driven Biomaterials Evolution
Suwardi, A., Wang, F., Xue, K., Han, M., Teo, P., Wang, P., Wang, S., Liu, Y., Ye, E., Li, Z., et al. (2022) · Advanced Materials · doi:10.1002/adma.202102703 · Cited by 299
Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver
Fan, W., Adebowale, K., Váncza, L., Li, Y., Rabbi, M. F., Kunimoto, K., Chen, D., Mozes, G., Chiu, D. K.-C., Li, Y., et al. (2024) · Nature · doi:10.1038/s41586-023-06991-9 · Cited by 263
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Metadata
- Authors
- Charrier, E. E., Pogoda, K., Wells, R. G., & Janmey, P. A.
- Venue
- Nature Communications
- Published
- 2018-01-31
- Volume
- 9
- Issue
- 1
- Pages
- 449-449
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2806056821
- Cited by
- 415
- References
- 2
- FWCI
- 21.07
- Type
- journal article
- Language
- en
- Open access
- gold
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