Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces
Open accessAbstract
A multitude of biological processes are enabled by complex interactions between lipid membranes and proteins. To understand such dynamic processes, it is crucial to differentiate the constituent biomolecular species and track their individual time evolution without invasive labels. Here, we present a label-free mid-infrared biosensor capable of distinguishing multiple analytes in heterogeneous biological samples with high sensitivity. Our technology leverages a multi-resonant metasurface to simultaneously enhance the different vibrational fingerprints of multiple biomolecules. By providing up to 1000-fold near-field intensity enhancement over both amide and methylene bands, our sensor resolves the interactions of lipid membranes with different polypeptides in real time. Significantly, we demonstrate that our label-free chemically specific sensor can analyze peptide-induced neurotransmitter cargo release from synaptic vesicle mimics. Our sensor opens up exciting possibilities for gaining new insights into biological processes such as signaling or transport in basic research as well as provides a valuable toolkit for bioanalytical and pharmaceutical applications.
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Multi-resonant plasmonic nanoantenna sensors collect broadband spectrum data to recognize lipids and proteins from separate absorption wavelengths.
“Therefore, to detect more absorption peaks in the MIR region, multi-resonant PNA sensors are proposed to collect broadband spectrum data to recognize lipids and proteins from separate absorption wavelengths39.”
From Wavelength-multiplexed hook nanoantennas for machine learning enabled mid-infrared spectroscopy (2022) · cites this paper as [39]
Previous works show many solutions using multiple resonances of nanoantenna structures to capture plasmonic enhanced molecular fingerprints in separate wavelength ranges for sensing different molecule species.
“Previous works show many solutions using multiple resonances of nanoantenna structures to capture the plasmonic enhanced molecular fingerprints in separate wavelength ranges for sensing different molecule species22,39,41,50,54–56.”
From Wavelength-multiplexed hook nanoantennas for machine learning enabled mid-infrared spectroscopy (2022) · cites this paper as [39]
In PNA-based SEIRAS, the great challenge is the limited bandwidth of nanoantenna resonances compared with the ultra-broadband vibrational absorption fingerprints.
“In PNA-based surface-enhanced IR absorption spectroscopy (SEIRAS), the great challenge is the limited bandwidth of nanoantenna resonances compared with the ultra-broadband vibrational absorption fingerprints.”
From Wavelength-multiplexed hook nanoantennas for machine learning enabled mid-infrared spectroscopy (2022) · cites this paper as [39]
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References 52 · Cited by 269
- Authors
- Rodrigo, D., Tittl, A., Ait-Bouziad, N., John-Herpin, A., Limaj, O., Kelly, C., Yoo, D., Wittenberg, N. J., Oh, S.-H., Lashuel, H. A., & Altug, H.
- Affiliations
- Institute of Photonic Sciences (ES)
- École Polytechnique Fédérale de Lausanne (CH)
- University of Minnesota (US)
- Corresponding author
- Altug, Hatice
- ORCID
- Venue
- Nature Communications
- Published
- 2018-06-04
- Volume
- 9
- Issue
- 1
- Pages
- 2160-2160
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC5986821
- OpenAlex
- W2805867715
- Cited by
- 269
- References
- 52
- Citations by year
- 2026: 19 · 2025: 40 · 2024: 39 · 2023: 38 · 2022: 41 · 2021: 32 · 2020: 25 · 2019: 27 · 2018: 8
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, cc-by)
- Funders
- European Commission (777714, 737071, HORIZON2020, 625673, 609416, 665667)
- École Polytechnique Fédérale de Lausanne (665667)
- Horizon 2020 Framework Programme (665667, 737071, 777714, FETOPEN-737071)
- H2020 European Research Council (682167)
- Topics
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Metamaterials and Metasurfaces Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Physical Sciences › Engineering › Biomedical Engineering › Plasmonic and Surface Plasmon Research
- Keywords
- infrared metasurfaces, label-free biosensing, lipid membranes, peptide-membrane interactions, neurotransmitter release, mid-infrared spectroscopy
- MeSH terms
- Circular Dichroism, Lipid Bilayers, Membrane Lipids, Membrane Proteins, Peptides, Protein Binding, Reproducibility of Results, Biosensing Techniques, Spectroscopy, Fourier Transform Infrared
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