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Local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer
Open accessAbstract
Combining whole exome sequencing, transcriptome profiling, and T cell repertoire analysis, we investigate the spatial features of surgically-removed biopsies from multiple loci in tumor masses of 15 patients with non-small cell lung cancer (NSCLC). This revealed that the immune microenvironment has high spatial heterogeneity such that intratumoral regional variation is as large as inter-personal variation. While the local total mutational burden (TMB) is associated with local T-cell clonal expansion, local anti-tumor cytotoxicity does not directly correlate with neoantigen abundance. Together, these findings caution against that immunological signatures can be predicted solely from TMB or microenvironmental analysis from a single locus biopsy.
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Multiplexed spatial transcriptomics methods and the application of expansion microscopy
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Metadata
- Authors
- Jia, Q., Wu, W., Wang, Y., Alexander, P. B., Sun, C., Gong, Z., Cheng, J.-N., Sun, H., Guan, Y., Xia, X., Yang, L., Yi, X., Wan, Y. Y., Wang, H., He, J., Futreal, P. A., Li, Q.-J., & Zhu, B.
- Venue
- Nature Communications
- Published
- 2018-12-18
- Volume
- 9
- Issue
- 1
- Pages
- 5361-5361
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2905562353
- Cited by
- 489
- References
- 20
- FWCI
- 12.30
- Type
- journal article
- Language
- en
- Open access
- gold
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