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Calcium-activated 14-3-3 proteins as a molecular switch in salt stress tolerance
Open accessAbstract
Calcium is a universal secondary messenger that triggers many cellular responses. However, it is unclear how a calcium signal is coordinately decoded by different calcium sensors, which in turn regulate downstream targets to fulfill a specific physiological function. Here we show that SOS2-LIKE PROTEIN KINASE5 (PKS5) can negatively regulate the Salt-Overly-Sensitive signaling pathway in Arabidopsis. PKS5 can interact with and phosphorylate SOS2 at Ser 294, promote the interaction between SOS2 and 14-3-3 proteins, and repress SOS2 activity. However, salt stress promotes an interaction between 14-3-3 proteins and PKS5, repressing its kinase activity and releasing inhibition of SOS2. We provide evidence that 14-3-3 proteins bind to Ca 2+, and that Ca 2+ modulates 14-3-3-dependent regulation of SOS2 and PKS5 kinase activity. Our results suggest that a salt-induced calcium signal is decoded by 14-3-3 and SOS3/SCaBP8 proteins, which selectively activate/inactivate the downstream protein kinases SOS2 and PKS5 to regulate Na+ homeostasis by coordinately mediating plasma membrane Na+/H+ antiporter and H+-ATPase activity.
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Cited by
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Zhou, H., Shi, H., Yang, Y., Feng, X., Chen, X., Xiao, F., Lin, H., & Guo, Y. (2024) · Journal of Genetics and Genomics · doi:10.1016/j.jgg.2023.08.007 · Cited by 677
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Siddiqui, M. H., Alamri, S., Nasir Khan, M., Corpas, F. J., Al-Amri, A. A., Alsubaie, Q. D., Ali, H. M., Kalaji, H. M., & Ahmad, P. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.122882 · Cited by 319
Designing salt stress‐resilient crops: Current progress and future challenges
Liang, X., Li, J., Yang, Y., Jiang, C., & Guo, Y. (2024) · Journal of Integrative Plant Biology · doi:10.1111/jipb.13599 · Cited by 292
Self-citationH + -ATPases in Plant Growth and Stress Responses
Li, Y., Zeng, H., Xu, F., Yan, F., & Xu, W. (2022) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-102820-114551 · Cited by 161
Metadata
- Authors
- Yang, Z., Wang, C., Xue, Y., Liu, X., Chen, S., Song, C., Yang, Y., & Guo, Y.
- Venue
- Nature Communications
- Published
- 2019-03-13
- Volume
- 10
- Issue
- 1
- Pages
- 1199-1199
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2922059199
- Cited by
- 279
- References
- 0
- FWCI
- 19.17
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yang, Z., Wang, C., Xue, Y., Liu, X., Chen, S., Song, C., Yang, Y., & Guo, Y. (2019). Calcium-activated 14-3-3 proteins as a molecular switch in salt stress tolerance. Nature Communications. https://doi.org/10.1038/s41467-019-09181-2
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