The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
Synthetic biology strategies for microbial biosynthesis of plant natural products
Open accessAbstract
Metabolic engineers endeavor to create a bio-based manufacturing industry using microbes to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically challenging to produce and are ubiquitous in medicines, flavors, and fragrances. Engineering PNP pathways into new hosts requires finding or modifying a suitable host to accommodate the pathway, planning and implementing a biosynthetic route to the compound, and discovering or engineering enzymes for missing steps. In this review, we describe recent developments in metabolic engineering at the level of host, pathway, and enzyme, and discuss how the field is approaching ever more complex biosynthetic opportunities.
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1 retracted
RETRACTED ARTICLE: A water-soluble DsbB variant that catalyzes disulfide-bond formation in vivo
Mizrachi, D., Robinson, M.-P., Ren, G., Ke, N., Berkmen, M., & DeLisa, M. P. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2409 · Cited by 16
RetractedCaspi, R., Billington, R., Ferrer, L., Foerster, H., Fulcher, C. A., Keseler, I. M., Kothari, A., Krummenacker, M., Latendresse, M., Mueller, L. A., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1164 · Cited by 3,395
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
Ro, D.-K., Paradise, E. M., Ouellet, M., Fisher, K. J., Newman, K. L., Ndungu, J. M., Ho, K. A., Eachus, R. A., Ham, T. S., Kirby, J., et al. (2006) · Nature · doi:10.1038/nature04640 · Cited by 2,805
Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture
Savile, C. K., Janey, J. M., Mundorff, E. C., Moore, J. C., Tam, S., Jarvis, W. R., Colbeck, J. C., Krebber, A., Fleitz, F. J., Brands, J., et al. (2010) · Science · doi:10.1126/science.1188934 · Cited by 1,756
Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli
Ajikumar, P. K., Xiao, W.-H., Tyo, K. E. J., Wang, Y., Simeon, F., Leonard, E., Mucha, O., Phon, T. H., Pfeifer, B., & Stephanopoulos, G. (2010) · Science · doi:10.1126/science.1191652 · Cited by 1,677
The sequence of sequencers: The history of sequencing DNA
Heather, J. M., & Chain, B. (2016) · Genomics · doi:10.1016/j.ygeno.2015.11.003 · Cited by 1,397
Engineering Cellular Metabolism
Nielsen, J., & Keasling, J. D. (2016) · Cell · doi:10.1016/j.cell.2016.02.004 · Cited by 1,378
Kemp elimination catalysts by computational enzyme design
Röthlisberger, D., Khersonsky, O., Wollacott, A. M., Jiang, L., DeChancie, J., Betker, J., Gallaher, J. L., Althoff, E. A., Zanghellini, A., Dym, O., et al. (2008) · Nature · doi:10.1038/nature06879 · Cited by 1,307
Synthetic protein scaffolds provide modular control over metabolic flux
Dueber, J. E., Wu, G. C., Malmirchegini, G. R., Moon, T. S., Petzold, C. J., Ullal, A. V., Prather, K. L. J., & Keasling, J. D. (2009) · Nature Biotechnology · doi:10.1038/nbt.1557 · Cited by 1,242
Caspi, R., Altman, T., Billington, R., Dreher, K., Foerster, H., Fulcher, C. A., Holland, T. A., Keseler, I. M., Kothari, A., Kubo, A., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1103 · Cited by 1,204
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Chaachouay, N., & Zidane, L. (2024) · Drugs and Drug Candidates · doi:10.3390/ddc3010011 · Cited by 1,081
Teka, T., Zhang, L., Ge, X., Li, Y., Han, L., & Yan, X. (2022) · Phytochemistry · doi:10.1016/j.phytochem.2022.113128 · Cited by 216
Biosensor and machine learning-aided engineering of an amaryllidaceae enzyme
d’Oelsnitz, S., Diaz, D. J., Kim, W., Acosta, D. J., Dangerfield, T. L., Schechter, M. W., Minus, M. B., Howard, J. R., Do, H., Loy, J. M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46356-y · Cited by 58
Hussain, M. H., Mohsin, M. Z., Zaman, W. Q., Yu, J., Zhao, X., Wei, Y., Zhuang, Y., Mohsin, A., & Guo, M. (2022) · Synthetic and Systems Biotechnology · doi:10.1016/j.synbio.2021.12.012 · Cited by 31
Ren, Z., Xue, Y., Xu, N., Feng, D., Geng, C., Wu, Y., Liu, D., Zhao, L., Zhang, X., Ma, H., et al. (2025) · Microbial Cell Factories · doi:10.1186/s12934-025-02857-z · Cited by 2
Metadata
- Authors
- Cravens, A., Payne, J., & Smolke, C. D.
- Venue
- Nature Communications
- Published
- 2019-05-13
- Volume
- 10
- Issue
- 1
- Pages
- 2142-2142
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2945456477
- Cited by
- 438
- References
- 93
- FWCI
- 12.89
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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