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Cited by 62Dementia and Cognitive Impairment ResearchNeurobiology of Language and BilingualismHistorical and Modern Theater Studies

A unified neurocognitive model of semantics language social behaviour and face recognition in semantic dementia

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Ding, Junhua, Chen, Keliang, Liu, Haoming, Huang, Lin, Chen, Yan, Lv, Yingru, Yang, Qing, Guo, Qihao +2 more·2020·Nature Communications
DOI 10.1038/s41467-020-16089-9PMC PMC7244491
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Abstract

The anterior temporal lobes (ATL) have become a key brain region of interest in cognitive neuroscience founded upon neuropsychological investigations of semantic dementia (SD). The purposes of this investigation are to generate a single unified model that captures the known cognitive-behavioural variations in SD and map these to the patients’ distribution of frontotemporal atrophy. Here we show that the degree of generalised semantic impairment is related to the patients’ total, bilateral ATL atrophy. Verbal production ability is related to total ATL atrophy as well as to the balance of left > right ATL atrophy. Apathy is found to relate positively to the degree of orbitofrontal atrophy. Disinhibition is related to right ATL and orbitofrontal atrophy, and face recognition to right ATL volumes. Rather than positing mutually-exclusive sub-categories, the data-driven model repositions semantics, language, social behaviour and face recognition into a continuous frontotemporal neurocognitive space.

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  • The bilateral ATLs have been linked extensively to their role in semantic processing; the lATL has been largely associated with verbal semantics, whereas the rATL has been largely associated with nonverbal semantics, particularly regarding visual and socioemotional knowledge.

    “The bilateral ATLs have been linked extensively to their role in semantic processing42; the lATL has been largely associated with verbal semantics, whereas the rATL has been largely associated with nonverbal semantics, particularly regarding visual and socioemotional knowledge.8,43”

    From Automated Speech Analysis to Differentiate Frontal and Right Anterior Temporal Lobe Atrophy in Frontotemporal Dementia (2025) · cites this paper as [43]

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References 132 · Cited by 62

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Authors
Ding, J., Chen, K., Liu, H., Huang, L., Chen, Y., Lv, Y., Yang, Q., Guo, Q., Han, Z., & Lambon Ralph, M. A.
Affiliations
  • Baylor College of Medicine (US)
  • Fudan University (CN)
  • Ca' Foscari University of Venice (IT)
  • Shanghai Jiao Tong University (CN)
  • Beijing Normal University (CN)
Corresponding author
Guo, Qihao
ORCID
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2020-05-22
Volume
11
Issue
1
Pages
2595-2595
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/s41467-020-16089-9
PMC
PMC7244491
OpenAlex
W3026393321
Cited by
62
References
132
Citations by year
2026: 2 · 2025: 8 · 2024: 15 · 2023: 14 · 2022: 7 · 2021: 12 · 2020: 4
FWCI
6.75
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Communications (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Apollo (University of Cambridge) (submittedVersion, cc-by)
  • Apollo (cc-by)
  • Apollo
Funders
  • Chinese Scholarship Council
  • National Key R&D Program of China
  • National Natural Science Foundation of China (81171019, 31872785)
  • Natural Science Foundation of Beijing Municipality (7182088)
  • RCUK | Medical Research Council (MR/R023883/1, MC_UU_00005/18)
  • ERC grant
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords
semantic dementia, anterior temporal lobe, frontotemporal lobar degeneration, semantic impairment, verbal production, apathy, disinhibition, face recognition (cognition), language, social behavior, neurocognitive model
MeSH terms
Facial Recognition, Aged, Atrophy, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Models, Neurological, Neuropsychological Tests, Social Behavior, Temporal Lobe, Case-Control Studies, Principal Component Analysis, Frontotemporal Dementia

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