Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging
Open accessAbstract
Real-time monitoring of vessel dysfunction is of great significance in preclinical research. Optical bioimaging in the second near-infrared (NIR-II) window provides advantages including high resolution and fast feedback. However, the reported molecular dyes are hampered by limited blood circulation time (~ 5–60 min) and short absorption and emission wavelength, which impede the accurate long-term monitoring. Here, we report a NIR-II molecule (LZ-1105) with absorption and emission beyond 1000 nm. Thanks to the long blood circulation time (half-life of 3.2 h), the fluorophore is used for continuous real-time monitoring of dynamic vascular processes, including ischemic reperfusion in hindlimbs, thrombolysis in carotid artery and opening and recovery of the blood brain barrier (BBB). LZ-1105 provides an approach for researchers to assess vessel dysfunction due to the long excitation and emission wavelength and long-term blood circulation properties.
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Cyanine dyes with varied energy gaps have been designed through structure modifications that allowed the development of fluorophores with emission greater than 1000 nm.
“Cyanine dyes with varied energy gaps have been designed through structure modifications that allowed the development of fluorophores with emission greater than 1000 nm.34−36”
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References 57 · Cited by 374
- Authors
- Li, B., Zhao, M., Feng, L., Dou, C., Ding, S., Zhou, G., Lu, L., Zhang, H., Chen, F., Li, X., Li, G., Zhao, S., Jiang, C., Wang, Y., Zhao, D., Cheng, Y., & Zhang, F.
- Affiliations
- Fudan University (CN)
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Zhang, Fan
- ORCID
- Venue
- Nature Communications
- Published
- 2020-06-18
- Volume
- 11
- Issue
- 1
- Pages
- 3102-3102
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC7303218
- OpenAlex
- W3036418258
- Cited by
- 374
- References
- 57
- Citations by year
- 2026: 33 · 2025: 51 · 2024: 70 · 2023: 68 · 2022: 73 · 2021: 60 · 2020: 19
- FWCI
- 26.77
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Griffith Research Online (submittedVersion, cc-by)
- Funders
- Chinese Ministry of Science and Technology | Department of S and T for Social Development (2017YFA0207303)
- National Natural Science Foundation of China (21725502, 51961145403)
- Science and Technology Commission of Shanghai Municipality (17JC1400100, 19490713100)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Keywords
- NIR-II fluorescence imaging, vascular imaging, ischemia-reperfusion injury, thrombolysis, blood-brain barrier, blood-brain barrier opening, carotid artery, hindlimb ischemia, molecular dyes, real-time monitoring
- MeSH terms
- Animals, Carotid Arteries, Female, Fluorescent Dyes, Hindlimb, Humans, Mice, Nude, Thrombosis, Vascular Diseases, Reperfusion Injury, Human Umbilical Vein Endothelial Cells
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