The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Genetic drug target validation using Mendelian randomisation
Open accessAbstract
Mendelian randomisation (MR) analysis is an important tool to elucidate the causal relevance of environmental and biological risk factors for disease. However, causal inference is undermined if genetic variants used to instrument a risk factor also influence alternative disease-pathways (horizontal pleiotropy). Here we report how the ‘no horizontal pleiotropy assumption’ is strengthened when proteins are the risk factors of interest. Proteins are typically the proximal effectors of biological processes encoded in the genome. Moreover, proteins are the targets of most medicines, so MR studies of drug targets are becoming a fundamental tool in drug development. To enable such studies, we introduce a mathematical framework that contrasts MR analysis of proteins with that of risk factors located more distally in the causal chain from gene to disease. We illustrate key model decisions and introduce an analytical framework for maximising power and evaluating the robustness of analyses.
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Cites
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Cited by
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Guidelines for performing Mendelian randomization investigations
Burgess, S., Davey Smith, G., Davies, N. M., Dudbridge, F., Gill, D., Glymour, M. M., Hartwig, F. P., Holmes, M. V., Minelli, C., Relton, C. L., et al. (2020) · Wellcome Open Research · doi:10.12688/wellcomeopenres.15555.2 · Cited by 1,273
Metadata
- Authors
- Schmidt, A. F., Finan, C., Gordillo-Marañón, M., Asselbergs, F. W., Freitag, D. F., Patel, R. S., Tyl, B., Chopade, S., Faraway, R., Zwierzyna, M., & Hingorani, A. D.
- Venue
- Nature Communications
- Published
- 2020-06-26
- Volume
- 11
- Issue
- 1
- Pages
- 3255-3255
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3037039951
- Cited by
- 567
- References
- 85
- FWCI
- 19.89
- Type
- journal article
- Language
- en
- Open access
- gold
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- Schmidt, A. F., Finan, C., Gordillo-Marañón, M., Asselbergs, F. W., Freitag, D. F., Patel, R. S., Tyl, B., Chopade, S., Faraway, R., Zwierzyna, M., & Hingorani, A. D. (2020). Genetic drug target validation using Mendelian randomisation. Nature Communications. https://doi.org/10.1038/s41467-020-16969-0
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