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High-speed three-dimensional photoacoustic computed tomography for preclinical research and clinical translation
Open accessAbstract
Photoacoustic computed tomography (PACT) has generated increasing interest for uses in preclinical research and clinical translation. However, the imaging depth, speed, and quality of existing PACT systems have previously limited the potential applications of this technology. To overcome these issues, we developed a three-dimensional photoacoustic computed tomography (3D-PACT) system that features large imaging depth, scalable field of view with isotropic spatial resolution, high imaging speed, and superior image quality. 3D-PACT allows for multipurpose imaging to reveal detailed angiographic information in biological tissues ranging from the rodent brain to the human breast. In the rat brain, we visualize whole brain vasculatures and hemodynamics. In the human breast, an in vivo imaging depth of 4 cm is achieved by scanning the breast within a single breath hold of 10 s. Here, we introduce the 3D-PACT system to provide a unique tool for preclinical research and an appealing prototype for clinical translation.
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Structural absorption by barbule microstructures of super black bird of paradise feathers
McCoy, D. E., Feo, T., Harvey, T. A., & Prum, R. O. (2018) · Nature Communications · doi:10.1038/s41467-017-02088-w · Cited by 7,424
Mapping oxygen concentration in the awake mouse brain
Lyons, D. G., Parpaleix, A., Roche, M., & Charpak, S. (2016) · eLife · doi:10.7554/elife.12024 · Cited by 165
Cited by
Stimuli-Responsive Polymer-Based Nanosystems for Cancer Theranostics
Wei, D., Sun, Y., Zhu, H., & Fu, Q. (2023) · ACS Nano · doi:10.1021/acsnano.3c06019 · Cited by 303
Metadata
- Authors
- Lin, L., Hu, P., Tong, X., Na, S., Cao, R., Yuan, X., Garrett, D. C., Shi, J., Maslov, K., & Wang, L. V.
- Venue
- Nature Communications
- Published
- 2021-02-09
- Volume
- 12
- Issue
- 1
- Pages
- 882-882
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3126411932
- Cited by
- 200
- References
- 2
- FWCI
- 9.38
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lin, L., Hu, P., Tong, X., Na, S., Cao, R., Yuan, X., Garrett, D. C., Shi, J., Maslov, K., & Wang, L. V. (2021). High-speed three-dimensional photoacoustic computed tomography for preclinical research and clinical translation. Nature Communications. https://doi.org/10.1038/s41467-021-21232-1
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