A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway
Open accessAbstract
One common cause of vision loss after retinal detachment surgery is the formation of proliferative and contractile fibrocellular membranes. This aberrant wound healing process is mediated by epithelial-mesenchymal transition (EMT) and hyper-proliferation of retinal pigment epithelial (RPE) cells. Current treatment relies primarily on surgical removal of these membranes. Here, we demonstrate that a bio-functional polymer by itself is able to prevent retinal scarring in an experimental rabbit model of proliferative vitreoretinopathy. This is mediated primarily via clathrin-dependent internalisation of polymeric micelles, downstream suppression of canonical EMT transcription factors, reduction of RPE cell hyper-proliferation and migration. Nuclear factor erythroid 2-related factor 2 signalling pathway was identified in a genome-wide transcriptomic profiling as a key sensor and effector. This study highlights the potential of using synthetic bio-functional polymer to modulate RPE cellular behaviour and offers a potential therapy for retinal scarring prevention.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A bio-functional polymer alone could prevent retinal scarring in an experimental rabbit model with PVR, primarily mediated through clathrin-dependent internalization of PMs, downstream suppression of canonical EMT transcription factors, reduction in hyper-proliferation and migration of RPE cells.
“In a recent study, researchers demonstrated that a bio-functional polymer alone could prevent retinal scarring in an experimental rabbit model with PVR. This process is primarily mediated through clathrin-dependent internalization of PMs, downstream suppression of canonical EMT transcription factors, reduction in hyper-proliferation and migration of RPE cells [190].”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [190]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 71 · Cited by 54
Research works printed but not linked: 4
- [2]Constable, I. J. & Nagpal, M. Retina 5th edn (eds Ryan, S. J. et al.) 1806–1825 (W.B. Saunders, 2013).
- [37]Zhao X Anti-angiogenic nanomicelles for the topical delivery of aflibercept to treat retinal neovascular disease Adv. Mater. 2021 n/a 2108360 10.1002/adma.202108360 34726299 · DOI · Paper page
- [60]Stanzel, B. et al. Pluripotent Stem Cells in Eye Disease Therapy 141–170 (Springer, 2019).
- [65]Blenkinsop, T. A., Salero, E., Stern, J. H. & Temple, S. Epithelial Cell Culture Protocols: Second Edition (eds Randell, S.H. & Fulcher, M.L.) 45–65 (Humana Press, 2013).
- Authors
- Parikh, B. H., Liu, Z., Blakeley, P., Lin, Q., Singh, M., Ong, J. Y., Ho, K. H., Lai, J. W., Bogireddi, H., Tran, K. C., Lim, J. Y. C., Xue, K., Al-Mubaarak, A., Yang, B., R, S., Regha, K., Wong, D. S. L., Tan, Q. S. W., Zhang, Z., Jeyasekharan, A. D., Barathi, V. A., Yu, W., Cheong, K. H., Blenkinsop, T. A., Hunziker, W., Lingam, G., Loh, X. J., & Su, X.
- Affiliations
- Agency for Science, Technology and Research (SG)
- National University of Singapore (SG)
- Singapore University of Technology and Design (SG)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Loh, Xian Jun
- Su, Xinyi
- ORCID
- Parikh, Bhav Harshad
- Liu, Zengping
- Blakeley, Paul
- Lin, Qianyu
- Singh, Malay
- Ong, Jun Yi
- Lai, Joel Weijia
- Tran, Kim Chi
- Lim, Jason Y. C.
- Xue, Kun
- Al-Mubaarak, Abdurrahmaan
- Yang, Binxia
- Wong, Daniel Soo Lin
- Zhang, Zhongxing
- Jeyasekharan, Anand D.
- Barathi, Veluchamy Amutha
- Yu, Weimiao
- Cheong, Kang Hao
- Blenkinsop, Timothy A.
- Hunziker, Walter
- Lingam, Gopal
- Loh, Xian Jun
- Su, Xinyi
- Venue
- Nature Communications
- Published
- 2022-05-19
- Volume
- 13
- Issue
- 1
- Pages
- 2796-2796
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC9119969
- OpenAlex
- W4280488233
- Cited by
- 54
- References
- 71
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 24 · 2023: 8 · 2022: 6
- FWCI
- 7.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Research Foundation Singapore (NRF-CRP21-2018-00103)
- Agency for Science, Technology and Research (H20H7a0034)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal and Macular Surgery
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinopathy of Prematurity Studies
- Keywords
- retinal scarring, proliferative vitreoretinopathy, retinal detachment, retinal pigment epithelium, epithelial-mesenchymal transition, Nrf2 signaling, polymeric micelles, clathrin-mediated endocytosis, RPE cell proliferation, blindness prevention
- MeSH terms
- Animals, Cell Line, Cell Movement, Cicatrix, Polymers, Rabbits, NF-E2-Related Factor 2, Retinal Pigment Epithelium, Epithelial-Mesenchymal Transition
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
