Gut microbiota and metabolites of α-synuclein transgenic monkey models with early stage of Parkinson’s disease
Open accessAbstract
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. However, it is unclear whether microbiota and metabolites have demonstrated changes at early PD due to the difficulties in diagnosis and identification of early PD in clinical practice. In a previous study, we generated A53T transgenic monkeys with early Parkinson’s symptoms, including anxiety and cognitive impairment. Here we analyzed the gut microbiota by metagenomic sequencing and metabolites by targeted gas chromatography. The gut microbiota analysis showed that the A53T monkeys have higher degree of diversity in gut microbiota with significantly elevated Sybergistetes, Akkermansia, and Eggerthella lenta compared with control monkeys. Prevotella significantly decreased in A53T transgenic monkeys. Glyceric acid, L-Aspartic acid, and p-Hydroxyphenylacetic acid were significantly elevated, whereas Myristic acid and 3-Methylindole were significantly decreased in A53T monkeys. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (KO0131) and the oxidative phosphorylation reaction (KO2147) were significantly increased in metabolic pathways of A53T monkeys. Our study suggested that the transgenic A53T and α-syn aggregation may affect the intestine microbiota and metabolites of rhesus monkeys, and the identified five compositional different metabolites that are mainly associated with mitochondrial dysfunction may be related to the pathogenesis of PD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several studies have reported a higher abundance of Akkermansia in PD patients compared to healthy controls.
“Several studies have reported a higher abundance of Akkermansia in PD patients compared to healthy controls [16, 53]”
From Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity <i>via</i> AMPK/SOD2 Pathway (2023) · cites this paper as [53]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 57 · Cited by 51
- Authors
- Yan, Y., Ren, S., Duan, Y., Lu, C., Niu, Y., Wang, Z., Inglis, B., Ji, W., Zheng, Y., & Si, W.
- Affiliations
- Kunming University of Science and Technology (CN)
- Corresponding author
- Ji, Weizhi
- Zheng, Yun
- Si, Wei
- Venue
- npj Biofilms and Microbiomes
- Published
- 2021-09-02
- Volume
- 7
- Issue
- 1
- Pages
- 69-69
- ISSN
- 2055-5008 (ISSN-L)
- PMC
- PMC8413421
- OpenAlex
- W3196653828
- Cited by
- 51
- References
- 57
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 13 · 2023: 9 · 2022: 16
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- npj Biofilms and Microbiomes (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Key Research and Development Program of China (2016YFA0101403, 2018YFA0801403)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Parkinson's disease, gut microbiota, microbial metabolites, rhesus monkeys, early-stage Parkinson's disease, alpha-synuclein aggregation, Akkermansia, Synergistetes, Eggerthella lenta, Prevotella, glyceric acid, p-hydroxyphenylacetic acid, L-aspartic acid, mitochondrial dysfunction, oxidative phosphorylation, glyceraldehyde-3-phosphate dehydrogenase, anxiety, cognitive impairment
- MeSH terms
- Gastrointestinal Microbiome, Animals, Disease Models, Animal, Female, Glyceraldehyde-3-Phosphate Dehydrogenases, Humans, Macaca mulatta, Male, Parkinson Disease, Neurodegenerative Diseases, Animals, Genetically Modified, Mice, alpha-Synuclein, Metagenomics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
