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Biomarkers of aging associated with past treatments in breast cancer survivors: when therapy-induced pathways turn out to be potential therapeutic targets
Open accessAbstract
In a recent paper in NPJ Breast Cancer , Scuric et al. 1 found that in breast cancer patients, chemotherapy and radiation exposure were associated with some biomarkers of aging in white blood cell (WBC) and in peripheral blood mononuclear cells (PBMCs). Elevated levels of sTNF-RII, a biomarker of pro-inflammatory activation, were also detected. These results were obtained 3–6 years after the completion of primary treatments.
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“Ageing exacerbates the toxicity of these treatments and, in addition, some of them can also accelerate the onset of age-related dysfunctions, rendering chemotherapy a potential inducer of premature ageing via induction of senescence and SASP 193,194 .”
From Senescence and cancer — role and therapeutic opportunities (2022) · cites this paper as [194]
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- Sulciner, M. L. et al. Resolvins suppress tumor growth and enhance cancer therapy. J. Exp. Med. 215, 115–140 (2018). · DOI
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Cited by
Sorted by citations
Cancer stem cells—Origins and biomarkers: Perspectives for targeted personalized therapies
Walcher, L., Kistenmacher, A.-K., Suo, H., Kitte, R., Dluczek, S., Strauß, A., Blaudszun, A.-R., Yevsa, T., Fricke, S., & Kossatz-Boehlert, U. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01280 · Cited by 1,007
Senescence and cancer — role and therapeutic opportunities
Schmitt, C. A., Wang, B., & Demaria, M. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00668-4 · Cited by 794
Metadata
- Authors
- Jabbour, W., & Wion, D.
- Affiliations
- Inserm (FR)
- Corresponding author
- Wion, Didier
- ORCID
- Wion, Didier
- Venue
- npj Breast Cancer
- Published
- 2018-03-06
- Volume
- 4
- Issue
- 1
- Pages
- 4-4
- ISSN
- 2374-4677 (ISSN-L)
- PMC
- PMC5840380
- OpenAlex
- W2790400829
- Cited by
- 2
- References
- 0
- Citations by year
- 2022: 1 · 2020: 1
- FWCI
- 0.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- npj Breast Cancer (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Epidemiology › Multiple and Secondary Primary Cancers
- Keywords
- aging biomarkers, breast cancer survivors, chemotherapy, radiotherapy, peripheral blood mononuclear cells, leukocytes, inflammation, therapeutic target, late effects of cancer treatment
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- CoChat. (2026). Citation check: Biomarkers of aging associated with past treatments in breast cancer survivors: when therapy-induced pathways turn out to be potential therapeutic targets. https://app.cochat.ai/papers/10.1038/s41523-018-0058-6
- The paper
- Jabbour, W., & Wion, D. (2018). Biomarkers of aging associated with past treatments in breast cancer survivors: when therapy-induced pathways turn out to be potential therapeutic targets. npj Breast Cancer. https://doi.org/10.1038/s41523-018-0058-6
