Multiomics Implicate Gut Microbiota in Altered Lipid and Energy Metabolism in Parkinson’s Disease
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Abstract
We aimed to investigate the link between serum metabolites, gut bacterial community composition, and clinical variables in Parkinson's disease (PD) and healthy control subjects (HC). A total of 124 subjects were part of the study (63 PD patients and 61 HC subjects). 139 metabolite features were found to be predictive between the PD and Control groups. No associations were found between metabolite features and within-PD clinical variables. The results suggest alterations in serum metabolite profiles in PD, and the results of correlation analysis between metabolite features and microbiota suggest that several bacterial taxa are associated with altered lipid and energy metabolism in PD.
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Because of dysbiosis, lipid, amino acid and energy metabolism are often dysregulated in Parkinson's disease patients.
“because of dysbiosis, lipid, amino acid and energy metabolism are often dysregulated in PD patients [96,97,98,99,100]”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [97]
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References 78 · Cited by 40
Research works printed but not linked: 3
- [11]Tan Gut microbial ecosystem in Parkinson disease: new clinicobiological insights from multi-omics Ann. Neurol. 2021 89 546 559 33274480
- [35]Utami OC Kurniawati Y Diba S Saleh MI Correlation between serum lipid profile and acne vulgaris severity J. Phys.: Conf. Ser. 2019 1246 012066
- [75]Silverman JD Roche K Holmes ZC David LA Mukherjee S Bayesian Multinomial Logistic Normal Models through Marginally Latent Matrix-T Processes J. Mach. Learn. Res 2022 23 1 42 PMC13061366 41958966
- Authors
- Pereira, P. A. B., Trivedi, D. K., Silverman, J., Duru, I. C., Paulin, L., Auvinen, P., & Scheperjans, F.
- Affiliations
- University of Helsinki (FI)
- University of Manchester (GB)
- Pennsylvania State University (US)
- Corresponding author
- Pereira, Pedro A. B.
- Scheperjans, Filip
- ORCID
- Venue
- npj Parkinson s Disease
- Published
- 2022-04-11
- Volume
- 8
- Issue
- 1
- Pages
- 39-39
- ISSN
- 2373-8057 (ISSN-L)
- PMC
- PMC9001728
- OpenAlex
- W4226150259
- Cited by
- 40
- References
- 78
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 6 · 2023: 7 · 2022: 5
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- npj Parkinson s Disease (publishedVersion, cc-by)
- medRxiv (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Työväentutkimus Vuosikirja (submittedVersion)
- Funders
- Academy of Finland (295724, 310835)
- Suomen Lääketieteen Säätiö
- Hospital District of Helsinki and Uusimaa (HUS) https://www.hus.fi/en/about-us
- Michael J. Fox Foundation for Parkinson’s Research
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Keywords
- Parkinson's disease, gut microbiota, serum metabolites, lipid metabolism, energy metabolism, multi-omics, bacterial taxa, metabolite profiles
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