The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data
Open accessAbstract
Small cell lung cancer (SCLC) is an exceptionally lethal malignancy for which more effective therapies are urgently needed. Several lines of evidence, from SCLC primary human tumours, patient-derived xenografts, cancer cell lines and genetically engineered mouse models, appear to be converging on a new model of SCLC subtypes defined by differential expression of four key transcription regulators: achaete-scute homologue 1 (ASCL1; also known as ASH1), neurogenic differentiation factor 1 (NeuroD1), yes-associated protein 1 (YAP1) and POU class 2 homeobox 3 (POU2F3). In this Perspectives article, we review and synthesize these recent lines of evidence and propose a working nomenclature for SCLC subtypes defined by relative expression of these four factors. Defining the unique therapeutic vulnerabilities of these subtypes of SCLC should help to focus and accelerate therapeutic research, leading to rationally targeted approaches that may ultimately improve clinical outcomes for patients with this disease. This Opinion, written by many leading experts in small cell lung cancer (SCLC) research, proposes a new model of SCLC subtypes defined by differential expression of four key transcription regulators. Such classification should help to focus and accelerate therapeutic research.
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Cites
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Self-citationSTK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS -Mutant Lung Adenocarcinoma
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Self-citationIntegrative genome analyses identify key somatic driver mutations of small-cell lung cancer
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Cited by
Rudin, C. M., Awad, M. M., Navarro, A., Gottfried, M., Peters, S., Csőszi, T., Cheema, P. K., Rodriguez-Abreu, D., Wollner, M., Yang, J. C.-H., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.20.00793 · Cited by 760
Self-citationGoldman, J. W., Dvorkin, M., Chen, Y., Reinmuth, N., Hotta, K., Trukhin, D., Statsenko, G., Hochmair, M. J., Özgüroğlu, M., Ji, J. H., et al. (2021) · The Lancet Oncology · doi:10.1016/s1470-2045(20)30539-8 · Cited by 688
Self-citationIreland, A. S., Micinski, A. M., Kastner, D. W., Guo, B., Wait, S. J., Spainhower, K. B., Conley, C. C., Chen, O. S., Guthrie, M. R., Soltero, D., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.05.001 · Cited by 508
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An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping
Kawasaki, K., Toshimitsu, K., Matano, M., Fujita, M., Fujii, M., Togasaki, K., Ebisudani, T., Shimokawa, M., Takano, A., Takahashi, S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.10.023 · Cited by 238
Metadata
- Authors
- Rudin, C. M., Poirier, J. T., Byers, L. A., Dive, C., Dowlati, A., George, J., Heymach, J. V., Johnson, J. E., Lehman, J. M., MacPherson, D., Massion, P. P., Minna, J. D., Oliver, T. G., Quaranta, V., Sage, J., Thomas, R. K., Vakoc, C. R., & Gazdar, A. F.
- Venue
- Nature Reviews Cancer
- Published
- 2019-03-29
- Volume
- 19
- Issue
- 5
- Pages
- 289-297
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2928432651
- Cited by
- 1,254
- References
- 64
- FWCI
- 14.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Rudin, C. M., Poirier, J. T., Byers, L. A., Dive, C., Dowlati, A., George, J., Heymach, J. V., Johnson, J. E., Lehman, J. M., MacPherson, D., Massion, P. P., Minna, J. D., Oliver, T. G., Quaranta, V., Sage, J., Thomas, R. K., Vakoc, C. R., & Gazdar, A. F. (2019). Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. Nature Reviews Cancer. https://doi.org/10.1038/s41568-019-0133-9
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