The DOI matches its Crossref record; 204 of the 204 references it cites were found in a registry or an index.
Brain immunology and immunotherapy in brain tumours
Open accessAbstract
Gliomas, the most common malignant primary brain tumours, remain universally lethal. Yet, seminal discoveries in the past 5 years have clarified the anatomy, genetics and function of the immune system within the central nervous system (CNS) and altered the paradigm for successful immunotherapy. The impact of standard therapies on the response to immunotherapy is now better understood, as well. This new knowledge has implications for a broad range of tumours that develop within the CNS. Nevertheless, the requirements for successful therapy remain effective delivery and target specificity, while the dramatic heterogeneity of malignant gliomas at the genetic and immunological levels remains a profound challenge. This Review discusses how advances in our understanding of the immune system within the brain have implications for the successful implementation of immunotherapy to treat brain tumours, despite challenges such as effective delivery, target specificity and intratumour heterogeneity.
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1 retracted
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Cited by
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T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas
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Metadata
- Authors
- Sampson, J. H., Gunn, M. D., Fecci, P. E., & Ashley, D. M.
- Venue
- Nature Reviews Cancer
- Published
- 2019-12-05
- Volume
- 20
- Issue
- 1
- Pages
- 12-25
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2994525341
- Cited by
- 722
- References
- 204
- FWCI
- 11.66
- Type
- journal article
- Language
- en
- Open access
- green
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- Sampson, J. H., Gunn, M. D., Fecci, P. E., & Ashley, D. M. (2020). Brain immunology and immunotherapy in brain tumours. Nature Reviews Cancer. https://doi.org/10.1038/s41568-019-0224-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
