Endothelial cell metabolism in cardiovascular physiology and disease
Open accessAbstract
Endothelial cells are multifunctional cells that form the inner layer of blood vessels and have a crucial role in vasoreactivity, angiogenesis, immunomodulation, nutrient uptake and coagulation. Endothelial cells have unique metabolism and are metabolically heterogeneous. The microenvironment and metabolism of endothelial cells contribute to endothelial cell heterogeneity and metabolic specialization. Endothelial cell dysfunction is an early event in the development of several cardiovascular diseases and has been shown, at least to some extent, to be driven by metabolic changes preceding the manifestation of clinical symptoms. Diabetes mellitus, hypertension, obesity and chronic kidney disease are all risk factors for cardiovascular disease. Changes in endothelial cell metabolism induced by these cardiometabolic stressors accelerate the accumulation of dysfunctional endothelial cells in tissues and the development of cardiovascular disease. In this Review, we discuss the diversity of metabolic programmes that control endothelial cell function in the cardiovascular system and how these metabolic programmes are perturbed in different cardiovascular diseases in a disease-specific manner. Finally, we discuss the potential and challenges of targeting endothelial cell metabolism for the treatment of cardiovascular diseases.
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References 168 · Cited by 74
- Authors
- Pasut, A., Lama, E., Van Craenenbroeck, A. H., Kroon, J., & Carmeliet, P.
- Affiliations
- VIB-KU Leuven Center for Cancer Biology (BE)
- Amsterdam University Medical Centers (NL)
- Khalifa University of Science and Technology (AE)
- Corresponding author
- Kroon, Jeffrey
- Carmeliet, Peter
- Venue
- Nature Reviews Cardiology
- Published
- 2025-05-09
- Volume
- 22
- Issue
- 12
- Pages
- 923-943
- ISSN
- 1759-5002 (ISSN-L)
- 1759-5010
- OpenAlex
- W4410217648
- Cited by
- 74
- References
- 168
- Citations by year
- 2026: 60 · 2025: 14
- FWCI
- 9.54
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- Locations
- Nature Reviews Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Lirias (submittedVersion, other-oa)
- Funders
- European Commission (101076407, 848109)
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- Vlaamse regering
- HORIZON EUROPE European Research Council (101055155)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- endothelial cell metabolism, endothelial dysfunction, cardiovascular disease, metabolic heterogeneity, diabetes mellitus, hypertension, obesity, chronic kidney disease, cardiometabolic risk factors, vasoreactivity, angiogenesis, coagulation
- MeSH terms
- Animals, Cardiovascular Diseases, Energy Metabolism, Humans, Endothelial Cells
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