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Cited by 499

The DOI matches its Crossref record; 333 of the 333 references it cites were found in a registry or an index.

Atrial fibrillation

Open access
Brundel, Bianca J. J. M., Ai, Xun, Hills, Mellanie True, Kuipers, Myrthe F., Lip, Gregory Y. H., de Groot, Natasja M. S.·2022·Nature Reviews Disease Primers
DOI 10.1038/s41572-022-00347-9
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Abstract

Atrial fibrillation (AF) is the most common cardiac arrhythmia despite substantial efforts to understand the pathophysiology of the condition and develop improved treatments. Identifying the underlying causative mechanisms of AF in individual patients is difficult and the efficacy of current therapies is suboptimal. Consequently, the incidence of AF is steadily rising and there is a pressing need for novel therapies. Research has revealed that defects in specific molecular pathways underlie AF pathogenesis, resulting in electrical conduction disorders that drive AF. The severity of this so-called electropathology correlates with the stage of AF disease progression and determines the response to AF treatment. Therefore, unravelling the molecular mechanisms underlying electropathology is expected to fuel the development of innovative personalized diagnostic tools and mechanism-based therapies. Moreover, the co-creation of AF studies with patients to implement novel diagnostic tools and therapies is a prerequisite for successful personalized AF management. Currently, various treatment modalities targeting AF-related electropathology, including lifestyle changes, pharmaceutical and nutraceutical therapy, substrate-based ablative therapy, and neuromodulation, are available to maintain sinus rhythm and might offer a novel holistic strategy to treat AF. Atrial fibrillation (AF) is the most common cardiac arrhythmia and is increasing in prevalence as populations age. This Primer provides an overview of AF epidemiology, the mechanisms underlying electropathology in AF, and the diagnostic approaches and treatments, and highlights important directions to improve understanding and management of AF in co-creation with patients.

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Metadata

Authors
Brundel, B. J. J. M., Ai, X., Hills, M. T., Kuipers, M. F., Lip, G. Y. H., & de Groot, N. M. S.
Venue
Nature Reviews Disease Primers
Publisher
Springer Science and Business Media LLC
Published
2022-04-07
Volume
8
Issue
1
Pages
21-21
ISSN
2056-676X (ISSN-L)
DOI
10.1038/s41572-022-00347-9
OpenAlex
W4223534056
Cited by
499
References
333
FWCI
30.55
Type
journal article
Language
en
Open access
hybrid
Licence

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CoChat. (2026). Citation check: Atrial fibrillation. https://app.cochat.ai/papers/10.1038/s41572-022-00347-9
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Brundel, B. J. J. M., Ai, X., Hills, M. T., Kuipers, M. F., Lip, G. Y. H., & de Groot, N. M. S. (2022). Atrial fibrillation. Nature Reviews Disease Primers. https://doi.org/10.1038/s41572-022-00347-9

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