Urgent need for further research in subclinical hypothyroidism
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T3 signaling and homeostasis in LT4-treated patients may not be fully restored in all tissues using LT4 alone.
“This suggests that T3 signaling and homeostasis in LT4-treated patients may not be fully restored in all tissues using LT4 alone (22).”
From Liothyronine and Desiccated Thyroid Extract in the Treatment of Hypothyroidism (2020) · cites this paper as [22]
The Abstract calls for biomarkers of tissue hypothyroidism and research into combining liothyronine with levothyroxine, which is consistent with uncertainty about LT4 replacement. It does not state that T3 signaling or homeostasis remains unrestored in any tissue of LT4-treated patients. (LLM, conf=0.77)
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Cites
Jonklaas, J., Bianco, A. C., Bauer, A. J., Burman, K. D., Cappola, A. R., Celi, F. S., Cooper, D. S., Kim, B. W., Peeters, R. P., Rosenthal, M. S., et al. (2014) · Thyroid® · doi:10.1089/thy.2014.0028 · Cited by 1,928 · see citing works
Self-citationGarber, J. R., Cobin, R. H., Gharib, H., Hennessey, J. V., Klein, I., Mechanick, J. I., Pessah-Pollack, R., Singer, P. A., & Woeber, K. A. (2012) · Endocrine Practice · doi:10.4158/ep12280.gl · Cited by 1,567 · see citing works
Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism
Stott, D. J., Rodondi, N., Kearney, P. M., Ford, I., Westendorp, R. G. J., Mooijaart, S. P., Sattar, N., Aubert, C. E., Aujesky, D., Bauer, D. C., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1603825 · Cited by 490 · see citing works
Feller, M., Snel, M., Moutzouri, E., Bauer, D. C., de Montmollin, M., Aujesky, D., Ford, I., Gussekloo, J., Kearney, P. M., Mooijaart, S., et al. (2018) · JAMA · doi:10.1001/jama.2018.13770 · Cited by 266 · see citing works
Razvi, S., Weaver, J. U., Butler, T. J., & Pearce, S. H. S. (2012) · Archives of Internal Medicine · doi:10.1001/archinternmed.2012.1159 · Cited by 266 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- [1]Bekkering GE Thyroid hormones treatment for subclinical hypothyroidism: a clinical practice guideline. BMJ 365, l2006 (2019). 31088853
- [3]Pearce SH 2013 ETA guideline: management of subclinical hypothyroidism. Eur. Thyroid J. 2, 215– 228 (2013). 24783053 PMC3923601
- [4]Chaker L Hypothyroidism. Lancet 390, 1550– 1562 (2017). 28336049 PMC6619426
- [8]Rodondi N Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA 304, 1365– 1374 (2010). 20858880 PMC3923470
- [10]Peterson SJ An online survey of hypothyroid patients demonstrates prominent dissatisfaction. Thyroid 28, 707– 721 (2018). 29620972 PMC6916129
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Taylor, P. N., Lansdown, A., Witczak, J., Khan, R., Rees, A., Dayan, C. M., & Okosieme, O. (2023) · Thyroid Research · doi:10.1186/s13044-023-00149-5 · Cited by 72 · see citing works
“A re-appraisal of the life-course of thyroid function is therefore timely and will have implications not only for clinical practice but also for clinical trials [27].”
BackgroundSelf-citationLiothyronine and Desiccated Thyroid Extract in the Treatment of Hypothyroidism
Idrees, T., Palmer, S., Maciel, R. M. B., & Bianco, A. C. (2020) · Thyroid® · doi:10.1089/thy.2020.0153 · Cited by 58 · see citing works
Self-citation
- Authors
- Taylor, P., & Bianco, A. C.
- Affiliations
- Cardiff University (GB)
- University of Chicago (US)
- Corresponding author
- Taylor, Peter
- Venue
- Nature Reviews Endocrinology
- Published
- 2019-07-12
- Volume
- 15
- Issue
- 9
- Pages
- 503-504
- ISSN
- 1759-5029 (ISSN-L)
- 1759-5037
- PMC
- PMC7309559
- OpenAlex
- W2960581074
- Cited by
- 14
- References
- 5
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 5
- Type
- other
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Reviews Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK077148)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- subclinical hypothyroidism, overtreatment, young adults, thyroid function, treatment thresholds, research gaps
- MeSH terms
- Humans, Hypothyroidism, Thyroid Hormones, Thyrotropin
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