The DOI matches its Crossref record; 193 of the 193 references it cites were found in a registry or an index.
The genetics of human ageing
Open accessAbstract
The past two centuries have witnessed an unprecedented rise in human life expectancy. Sustaining longer lives with reduced periods of disability will require an understanding of the underlying mechanisms of ageing, and genetics is a powerful tool for identifying these mechanisms. Large-scale genome-wide association studies have recently identified many loci that influence key human ageing traits, including lifespan. Multi-trait loci have been linked with several age-related diseases, suggesting shared ageing influences. Mutations that drive accelerated ageing in prototypical progeria syndromes in humans point to an important role for genome maintenance and stability. Together, these different strands of genetic research are highlighting pathways for the discovery of anti-ageing interventions that may be applicable in humans. Bringing together different strands of genetic research, including results from recent large-scale genome-wide association studies relevant to human ageing, the authors highlight how genetics can further our understanding of the underlying mechanisms of ageing.
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Cites
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Metadata
- Authors
- Melzer, D., Pilling, L. C., & Ferrucci, L.
- Venue
- Nature Reviews Genetics
- Published
- 2019-11-05
- Volume
- 21
- Issue
- 2
- Pages
- 88-101
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2988912149
- Cited by
- 363
- References
- 193
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- green
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