The DOI matches its Crossref record; 323 of the 338 references it cites were found in a registry or an index.
Dynamic alternative DNA structures in biology and disease
Open accessAbstract
Repetitive elements in the human genome, once considered 'junk DNA', are now known to adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed hairpins, left-handed Z-DNA, three-stranded triplexes (H-DNA) or four-stranded guanine quadruplex structures (G4 DNA). These dynamic conformations can act as functional genomic elements involved in DNA replication and transcription, chromatin organization and genome stability. In addition, recent studies have revealed a role for these alternative structures in triggering error-generating DNA repair processes, thereby actively enabling genome plasticity. As a driving force for genetic variation, non-B DNA structures thus contribute to both disease aetiology and evolution.
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“Notably, G4s and non-B DNA structures in general have been shown to trigger genomic instability through wrongfully stimulating DNA damage and repair responses which initially maintain genome integrity.”
From G-quadruplex-mediated genomic instability drives SNVs in cancer (2024) · cites this paper as [82]
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Citations
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Metadata
- Authors
- Wang, G., & Vasquez, K. M.
- Affiliations
- The University of Texas at Austin (US)
- Venue
- Nature Reviews Genetics
- Published
- 2022-10-31
- Volume
- 24
- Issue
- 4
- Pages
- 211-234
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- PMC
- PMC11634456
- OpenAlex
- W4307744067
- Cited by
- 196
- References
- 338
- Citations by year
- 2026: 52 · 2025: 68 · 2024: 57 · 2023: 18 · 2022: 1
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA093729)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Keywords
- non-B DNA structures, Z-DNA, H-DNA, triplex DNA, G-quadruplex, repetitive elements, genome stability, mutagenesis, DNA repair, DNA replication, transcription, chromatin organization, genomic instability, etiology, evolution
- MeSH terms
- Biology, DNA, DNA Replication, Humans, Genome, Human, G-Quadruplexes
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