The type I interferon response in COVID-19: implications for treatment
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The timing of type I interferon induction is critical: early interferon appears protective, while later it may be less useful for viral control or may drive immunopathology.
“The timing of induction of type I interferon (or type III interferon in mucosal tissue) is crucial as the presence of type I interferon early in infection appears to be protective, whereas its relevance for viral control at later time points may be reduced or may even contribute to immunopathology57,71,72.”
From Immunological mechanisms of vaccine-induced protection against COVID-19 in humans (2021) · cites this paper as [57]
SARS-CoV-2 evades innate immunity through several mechanisms, suggesting innate responses are probably essential for protection.
“Like other pathogenic respiratory RNA viruses (including other coronaviruses, respiratory syncytial virus and enteroviruses)55, SARS-CoV-2 can evade innate immune responses via multiple mechanisms55,56, indicating that innate immunity is likely crucial for host protection54,57.”
From Immunological mechanisms of vaccine-induced protection against COVID-19 in humans (2021) · cites this paper as [57]
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Cites
Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
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Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients
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Longitudinal analyses reveal immunological misfiring in severe COVID-19
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The cGAS–STING pathway drives type I IFN immunopathology in COVID-19
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- Authors
- Lee, J. S., & Shin, E.-C.
- Affiliations
- Korea Advanced Institute of Science and Technology (KR)
- Corresponding author
- Shin, Eui-Cheol
- Venue
- Nature Reviews Immunology
- Published
- 2020-08-12
- Volume
- 20
- Issue
- 10
- Pages
- 585-586
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC8824445
- OpenAlex
- W3048867192
- Cited by
- 421
- References
- 8
- Citations by year
- 2026: 12 · 2025: 25 · 2024: 41 · 2023: 60 · 2022: 107 · 2021: 131 · 2020: 45
- FWCI
- 30.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Samsung Science and Technology Foundation (SSTF-BA1402-51)
- Samsung
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- type I interferon response, COVID-19 pandemic, SARS-CoV-2, hyperinflammation, severe COVID-19, interferon therapy, JAK inhibitors, cytokine storm
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Interleukin-6 Inhibitors, Interferon Lambda, Azetidines, Gene Expression Regulation, Humans, Immunity, Cellular, Interferons, Interleukin-1, Interleukins, Lung, Pneumonia, Viral, Purines, Pyrazoles, Severity of Illness Index, Sulfonamides, Tumor Necrosis Factor-alpha, Interleukin-6, Interferon-alpha, Interferon-beta, Coronavirus Infections, Interferon Regulatory Factors, Janus Kinase 1, Immunity, Humoral, Pandemics
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